Thyroid remnant radioiodine ablation with recombinant human thyrotropin

R. Michael Tuttle; Richard J. Robbins

doi:10.1007/978-1-59259-995-0_27

Thyroid remnant radioiodine ablation with recombinant human thyrotropin

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The primary treatment modalities for most patients with differentiated thyroid cancer include total thyroidectomy and radioactive iodine (RAI) remnant ablation (RRA; 1). The goal of RRA is to eliminate not only normal thyroid cells but also to destroy any residual microscopic thyroid carcinoma that may remain following total thyroidectomy and appropriate lymph node dissection. As reviewed in Chapters 14, 26, 32, and 88, RAI uptake into thyroid cells is enhanced by a lowiodine diet and thyrotropin (TSH) stimulation. For the past 40-50 yr, endogenous TSH production was stimulated by several weeks of thyroid hormone withdrawal prior to RAI dosing. However, thyroid hormone withdrawal often results in hypothyroid symptoms that are not well tolerated by many patients.

Original language	English (US)
Title of host publication	Thyroid Cancer (Second Edition)
Subtitle of host publication	A Comprehensive Guide to Clinical Management
Publisher	Humana Press
Pages	283-286
Number of pages	4
ISBN (Print)	9781588294623
DOIs	https://doi.org/10.1007/978-1-59259-995-0_27
State	Published - Dec 1 2006

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-59259-995-0_27

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abstract = "The primary treatment modalities for most patients with differentiated thyroid cancer include total thyroidectomy and radioactive iodine (RAI) remnant ablation (RRA; 1). The goal of RRA is to eliminate not only normal thyroid cells but also to destroy any residual microscopic thyroid carcinoma that may remain following total thyroidectomy and appropriate lymph node dissection. As reviewed in Chapters 14, 26, 32, and 88, RAI uptake into thyroid cells is enhanced by a lowiodine diet and thyrotropin (TSH) stimulation. For the past 40-50 yr, endogenous TSH production was stimulated by several weeks of thyroid hormone withdrawal prior to RAI dosing. However, thyroid hormone withdrawal often results in hypothyroid symptoms that are not well tolerated by many patients.",

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AB - The primary treatment modalities for most patients with differentiated thyroid cancer include total thyroidectomy and radioactive iodine (RAI) remnant ablation (RRA; 1). The goal of RRA is to eliminate not only normal thyroid cells but also to destroy any residual microscopic thyroid carcinoma that may remain following total thyroidectomy and appropriate lymph node dissection. As reviewed in Chapters 14, 26, 32, and 88, RAI uptake into thyroid cells is enhanced by a lowiodine diet and thyrotropin (TSH) stimulation. For the past 40-50 yr, endogenous TSH production was stimulated by several weeks of thyroid hormone withdrawal prior to RAI dosing. However, thyroid hormone withdrawal often results in hypothyroid symptoms that are not well tolerated by many patients.

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Thyroid remnant radioiodine ablation with recombinant human thyrotropin

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