Thymoma and hypogammaglobulinaemia with and without T suppressor cells

M. K. Brenner, J. G.E. Reittie, H. R. Chadda, A. Pollock, G. L. Asherson

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Patients with acquired hypogammaglobulinaemia usually have near normal numbers of B cells and normal T cell function. When hypogammaglobulinaemia occurs in association with thymoma, then B cell numbers have been reported as low, and distinctive T cells are present which inhibit immunoglobulin production by normal cells. It has been suggested that these T cells are responsible for the observed hypogammaglobulinaemia. We report a patient with thymoma and hypogammaglobulinaemia who lacks these distinctive suppressor cells and has normal B cell numbers. It is therefore incorrect to propose a single pathogenic mechanism for hypogammaglobulinaemia in association with thymoma.

Original languageEnglish (US)
Pages (from-to)619-624
Number of pages6
JournalClinical and Experimental Immunology
Volume58
Issue number3
StatePublished - 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Thymoma and hypogammaglobulinaemia with and without T suppressor cells'. Together they form a unique fingerprint.

Cite this