Thymic carcinoma with rhabdoid features

Tushar H. Toprani; Pheroze Tamboli; Mitual B. Amin; Nelson G. Ordoñez; Alberto Ayala; Jae Ro

doi:10.1053/adpa.2003.50007

Thymic carcinoma with rhabdoid features

Tushar H. Toprani, Pheroze Tamboli, Mitual B. Amin, Nelson G. Ordoñez, Alberto Ayala, Jae Ro

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A case of thymic carcinoma with rhabdoid differentiation is presented. A 67-year-old man who presented with chest pain and hemoptysis was referred to The University of Texas M. D. Anderson Cancer Center (Houston, TX). Radiologic studies revealed a large anterior mediastinal mass. After the initial biopsy and preoperative chemotherapy, a radical thymectomy revealed a stage III thymic carcinoma with a rhabdoid component. The rhabdoid component was characterized by large cells with an eccentric nucleus, prominent nucleolus, and typical paranuclear cytoplasmic inclusions. Immunohistochemical and electron microscopic studies confirmed the presence of rhabdoid cells with the paranuclear cytoplasmic inclusions staining for both pancytokeratin and vimentin. The patient was given postoperative chemotherapy and radiation. He has since developed metastases to the pelvis and is alive with disease at 20 months of follow-up. To our knowledge, this is the first reported case of thymic carcinoma with rhabdoid features.

Original language	English (US)
Pages (from-to)	106-111
Number of pages	6
Journal	Annals of Diagnostic Pathology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1053/adpa.2003.50007
State	Published - Jan 1 2003

Keywords

Electron microscopy
Immunohistochemistry
Rhabdoid tumor
Thymic carcinoma

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1053/adpa.2003.50007

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title = "Thymic carcinoma with rhabdoid features",

abstract = "A case of thymic carcinoma with rhabdoid differentiation is presented. A 67-year-old man who presented with chest pain and hemoptysis was referred to The University of Texas M. D. Anderson Cancer Center (Houston, TX). Radiologic studies revealed a large anterior mediastinal mass. After the initial biopsy and preoperative chemotherapy, a radical thymectomy revealed a stage III thymic carcinoma with a rhabdoid component. The rhabdoid component was characterized by large cells with an eccentric nucleus, prominent nucleolus, and typical paranuclear cytoplasmic inclusions. Immunohistochemical and electron microscopic studies confirmed the presence of rhabdoid cells with the paranuclear cytoplasmic inclusions staining for both pancytokeratin and vimentin. The patient was given postoperative chemotherapy and radiation. He has since developed metastases to the pelvis and is alive with disease at 20 months of follow-up. To our knowledge, this is the first reported case of thymic carcinoma with rhabdoid features.",

keywords = "Electron microscopy, Immunohistochemistry, Rhabdoid tumor, Thymic carcinoma",

author = "Toprani, {Tushar H.} and Pheroze Tamboli and Amin, {Mitual B.} and Ordo{\~n}ez, {Nelson G.} and Alberto Ayala and Jae Ro",

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doi = "10.1053/adpa.2003.50007",

language = "English (US)",

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T1 - Thymic carcinoma with rhabdoid features

AU - Toprani, Tushar H.

AU - Tamboli, Pheroze

AU - Amin, Mitual B.

AU - Ordoñez, Nelson G.

AU - Ayala, Alberto

AU - Ro, Jae

PY - 2003/1/1

Y1 - 2003/1/1

N2 - A case of thymic carcinoma with rhabdoid differentiation is presented. A 67-year-old man who presented with chest pain and hemoptysis was referred to The University of Texas M. D. Anderson Cancer Center (Houston, TX). Radiologic studies revealed a large anterior mediastinal mass. After the initial biopsy and preoperative chemotherapy, a radical thymectomy revealed a stage III thymic carcinoma with a rhabdoid component. The rhabdoid component was characterized by large cells with an eccentric nucleus, prominent nucleolus, and typical paranuclear cytoplasmic inclusions. Immunohistochemical and electron microscopic studies confirmed the presence of rhabdoid cells with the paranuclear cytoplasmic inclusions staining for both pancytokeratin and vimentin. The patient was given postoperative chemotherapy and radiation. He has since developed metastases to the pelvis and is alive with disease at 20 months of follow-up. To our knowledge, this is the first reported case of thymic carcinoma with rhabdoid features.

AB - A case of thymic carcinoma with rhabdoid differentiation is presented. A 67-year-old man who presented with chest pain and hemoptysis was referred to The University of Texas M. D. Anderson Cancer Center (Houston, TX). Radiologic studies revealed a large anterior mediastinal mass. After the initial biopsy and preoperative chemotherapy, a radical thymectomy revealed a stage III thymic carcinoma with a rhabdoid component. The rhabdoid component was characterized by large cells with an eccentric nucleus, prominent nucleolus, and typical paranuclear cytoplasmic inclusions. Immunohistochemical and electron microscopic studies confirmed the presence of rhabdoid cells with the paranuclear cytoplasmic inclusions staining for both pancytokeratin and vimentin. The patient was given postoperative chemotherapy and radiation. He has since developed metastases to the pelvis and is alive with disease at 20 months of follow-up. To our knowledge, this is the first reported case of thymic carcinoma with rhabdoid features.

KW - Electron microscopy

KW - Immunohistochemistry

KW - Rhabdoid tumor

KW - Thymic carcinoma

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JO - Annals of Diagnostic Pathology

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SN - 1092-9134

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Thymic carcinoma with rhabdoid features

Abstract

Keywords

ASJC Scopus subject areas

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