Thymic carcinoma with rhabdoid features

Tushar H. Toprani, Pheroze Tamboli, Mitual B. Amin, Nelson G. Ordoñez, Alberto Ayala, Jae Ro

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

A case of thymic carcinoma with rhabdoid differentiation is presented. A 67-year-old man who presented with chest pain and hemoptysis was referred to The University of Texas M. D. Anderson Cancer Center (Houston, TX). Radiologic studies revealed a large anterior mediastinal mass. After the initial biopsy and preoperative chemotherapy, a radical thymectomy revealed a stage III thymic carcinoma with a rhabdoid component. The rhabdoid component was characterized by large cells with an eccentric nucleus, prominent nucleolus, and typical paranuclear cytoplasmic inclusions. Immunohistochemical and electron microscopic studies confirmed the presence of rhabdoid cells with the paranuclear cytoplasmic inclusions staining for both pancytokeratin and vimentin. The patient was given postoperative chemotherapy and radiation. He has since developed metastases to the pelvis and is alive with disease at 20 months of follow-up. To our knowledge, this is the first reported case of thymic carcinoma with rhabdoid features.

Original languageEnglish (US)
Pages (from-to)106-111
Number of pages6
JournalAnnals of Diagnostic Pathology
Volume7
Issue number2
DOIs
StatePublished - Jan 1 2003

Keywords

  • Electron microscopy
  • Immunohistochemistry
  • Rhabdoid tumor
  • Thymic carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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