Thrombotic thrombocytopenic purpura occurring despite absence of the spleen: Report of a case

D. M. Shapiro, G. W. Zeluff, K. Wilson, Ethan Natelson, E. C. Lynch

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a fulminant disorder characterized by widespread intravascular platelet deposition. At one time TTP was considered to be rapidly fatal. However, the use of splenectomy, corticosteroids, and recently, platelet activity modifying drugs (PAMD) may be changing the prognosis. Many authorities consider the spleen to play a major role in the pathogenesis of TTP and recommend early splenectomy. The occurrence of TTP 12 years after splenectomy, reported here, suggests that reappraisal be given to what role(s) the spleen plays in the etiology and treatment of this disorder. The use and rationale of PAMD therapy is also discussed.

Original languageEnglish (US)
Pages (from-to)798-802
Number of pages5
JournalJournal of the American Osteopathic Association
Volume75
Issue number9
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Complementary and alternative medicine

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