Thrombotic thrombocytopenic purpura (TTP) is a fulminant disorder characterized by widespread intravascular platelet deposition. At one time TTP was considered to be rapidly fatal. However, the use of splenectomy, corticosteroids, and recently, platelet activity modifying drugs (PAMD) may be changing the prognosis. Many authorities consider the spleen to play a major role in the pathogenesis of TTP and recommend early splenectomy. The occurrence of TTP 12 years after splenectomy, reported here, suggests that reappraisal be given to what role(s) the spleen plays in the etiology and treatment of this disorder. The use and rationale of PAMD therapy is also discussed.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of the American Osteopathic Association|
|State||Published - 1976|
ASJC Scopus subject areas
- Complementary and alternative medicine