Three suppressor systems in human blood that modulate lymphoproliferation

Lawrence Rice, A. H. Laughter, J. J. Twomey

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

Three suppressor systems of T lymphocyte proliferation found in normal blood were characterized. The adherent cell suppressor system (ACSS) is effected by a steroid and radioresistant monocyte that survives well in culture. The prostaglandin-related suppressor system (PgSS) is effected by a similar cell but is distinct from the ACSS in terms of magnitude of suppression, effective monocyte concentration, and carrageenan or indomethacin sensitivity. The induced suppressor system (ISS) is effected by a T lymphocyte that is partially radiosensitive and loses activity after 24 hr in cutlure. Although the ISS is unaffected by age, ACSS and PgSS activity is, overall, higher among elderly than among young adult subjects. Activation of these three suppressor systems does not require cell replication. They are not restricted by histocompatibility barriers.

Original languageEnglish (US)
Pages (from-to)991-996
Number of pages6
JournalJournal of Immunology
Volume122
Issue number3
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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