Three pathogenic determinants in immune nephritis - Anti-glomerular antibody specificity, innate triggers and host genetics

Tianfu Wu; Chandra Mohan

doi:10.2741/2223

Three pathogenic determinants in immune nephritis - Anti-glomerular antibody specificity, innate triggers and host genetics

Tianfu Wu, Chandra Mohan

Research Institute

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The prevailing notion is that lupus nephritis is mediated by autoantibodies, particularly those that bind to DNA and /or glomeruli. However it has become apparent that the development of immune-mediated renal disease is contingent upon additional factors including innate stimuli and host genetics. The purpose of this review is to evaluate our current understanding of three factors that can potentially influence immune-mediated renal disease: (1) Anti-glomerular/DNA antibodies (Abs), (2) Innate triggers, including Toll-Like Receptor (TLR) stimulation, and (3) the genetic makeup of the host.

Original language	English (US)
Pages (from-to)	2207-2211
Number of pages	5
Journal	Frontiers in Bioscience
Volume	12
Issue number	6
DOIs	https://doi.org/10.2741/2223
State	Published - Jan 1 2007

Keywords

Autoantibody
Immune Nephritis
Kidney
Mouse model
Nephritis
Pathogenic Determinants
Review
SLE
Systemic Lupus Erythromatosus

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Medicine(all)

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abstract = "The prevailing notion is that lupus nephritis is mediated by autoantibodies, particularly those that bind to DNA and /or glomeruli. However it has become apparent that the development of immune-mediated renal disease is contingent upon additional factors including innate stimuli and host genetics. The purpose of this review is to evaluate our current understanding of three factors that can potentially influence immune-mediated renal disease: (1) Anti-glomerular/DNA antibodies (Abs), (2) Innate triggers, including Toll-Like Receptor (TLR) stimulation, and (3) the genetic makeup of the host.",

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Three pathogenic determinants in immune nephritis - Anti-glomerular antibody specificity, innate triggers and host genetics

Abstract

Keywords

ASJC Scopus subject areas

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