Three pathogenic determinants in immune nephritis - Anti-glomerular antibody specificity, innate triggers and host genetics

Tianfu Wu, Chandra Mohan

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations

    Abstract

    The prevailing notion is that lupus nephritis is mediated by autoantibodies, particularly those that bind to DNA and /or glomeruli. However it has become apparent that the development of immune-mediated renal disease is contingent upon additional factors including innate stimuli and host genetics. The purpose of this review is to evaluate our current understanding of three factors that can potentially influence immune-mediated renal disease: (1) Anti-glomerular/DNA antibodies (Abs), (2) Innate triggers, including Toll-Like Receptor (TLR) stimulation, and (3) the genetic makeup of the host.

    Original languageEnglish (US)
    Pages (from-to)2207-2211
    Number of pages5
    JournalFrontiers in Bioscience
    Volume12
    Issue number6
    DOIs
    StatePublished - Jan 1 2007

    Keywords

    • Autoantibody
    • Immune Nephritis
    • Kidney
    • Mouse model
    • Nephritis
    • Pathogenic Determinants
    • Review
    • SLE
    • Systemic Lupus Erythromatosus

    ASJC Scopus subject areas

    • General Biochemistry, Genetics and Molecular Biology
    • General Immunology and Microbiology
    • General Medicine

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