Three-dimensional dendritic spine detection based on minimal cross-sectional curvature

Tiancheng He, Zhong Xue, Yong Kim, Stephen T. Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

The morphological changes of dendritic spines play a role in adaptive changes of the bram, and dysregulation of them is implicated in various neurological disorders. A systematic analysis tool for the morphology of dendritic spines, acquired via high resolution optical microscopy, should contribute to our understanding of neurophysiology as well as neuropathology. However, large numbers of high-resolution dendritic spine images make manual labeling extremely difficult and laborious. This is particularly challenging for the slender and curved dendritic spines frequently found in the striatum, dysregulation of which is highly implicated in neuropsychiatrie diseases, especially when compared to the analysis of relatively small and bulbous dendritic spines in other bram areas, including the hippocampus and cortex, synaptic dysregulation and neurodegeneration, of which are implicated in Alzheimer's disease. In this paper, we present cross-sectional curvature, a new feature, for detecting the tip of dendritic spines in stnatal neurons, the spines of which are then segmented using the region growing strategy. Comparative results showed that our method was more accurate and superior to the existing ones.

Original languageEnglish (US)
Title of host publication2012 9th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI 2012 - Proceedings
Pages1639-1642
Number of pages4
DOIs
StatePublished - Aug 15 2012
Event2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
Duration: May 2 2012May 5 2012

Other

Other2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
CountrySpain
CityBarcelona
Period5/2/125/5/12

Keywords

  • cross-sectional curvature
  • Dendritic spine labeling
  • neuron image
  • segmentation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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