Third Nerve Palsy as the Presenting Sign of Metastatic Endometrial Carcinoma with Lymphovascular Space Invasion

Weijie Violet Lin, Maria Miguelina De La Garza, Aroucha Vickers, Hamza Pasha, Suzanne Zein-Eldin Powell, Andrew G. Lee

Research output: Contribution to journalArticle

Abstract

We present a case of endometrial carcinoma (EC) presenting with a third cranial nerve palsy due to metastasis to the cavernous sinus. Although the tumour was only stage 1B, histopathologic features including higher grade and lymphovascular space invasion (LVSI) increase the risk of recurrent and metastatic disease. To our knowledge, this is the first case of EC presenting as a third cranial nerve palsy in the English-language ophthalmic literature. Clinicians should be aware that the risk of metastatic EC including neuro-ophthalmic presentations depends upon not only stage and grade but also the presence of unique histopathological findings such as LVSI.

Original languageEnglish (US)
Pages (from-to)397-400
Number of pages4
JournalNeuro-Ophthalmology
Volume43
Issue number6
DOIs
StatePublished - Nov 2 2019

Keywords

  • Third nerve palsy
  • endometrial cancer
  • lymphovascular space invasion (LVSI)
  • metastasis

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

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