Abstract
The synthesis and the X-ray structure of 16a-thiocamptothecin (TCPT), the thiopyridone analog of camptothecin (CPT), are accomplished. The crystal contains two structurally identical, yet independent molecules. Both of them are connected to other molecules via two intermolecular hydrogen bonds. S-Methylation of TCPT leads to the cleavage of the C-ring. The cytotoxic activity of TCPT was evaluated against different human tumor cell lines using CPT as reference compound.
Original language | English (US) |
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Pages (from-to) | 3040-3044 |
Number of pages | 5 |
Journal | Journal of Medicinal Chemistry |
Volume | 51 |
Issue number | 10 |
DOIs | |
State | Published - May 22 2008 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery