Thiocamptothecin

Cristian Samorì, Andrea Guerrini, Greta Varchi, Franco Zunino, Giovanni Luca Beretta, Cristina Femoni, Ezio Bombardelli, Gabriele Fontana, Arturo Battaglia

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The synthesis and the X-ray structure of 16a-thiocamptothecin (TCPT), the thiopyridone analog of camptothecin (CPT), are accomplished. The crystal contains two structurally identical, yet independent molecules. Both of them are connected to other molecules via two intermolecular hydrogen bonds. S-Methylation of TCPT leads to the cleavage of the C-ring. The cytotoxic activity of TCPT was evaluated against different human tumor cell lines using CPT as reference compound.

Original languageEnglish (US)
Pages (from-to)3040-3044
Number of pages5
JournalJournal of Medicinal Chemistry
Volume51
Issue number10
DOIs
StatePublished - May 22 2008

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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