Therapeutic transdifferentiation: can we generate cardiac tissue rather than scar after myocardial injury?

Nazish Sayed; Wing T.ak Wong; John P. Cooke

doi:10.14797/mdcj-9-4-210

Therapeutic transdifferentiation: can we generate cardiac tissue rather than scar after myocardial injury?

Nazish Sayed, Wing T.ak Wong, John P. Cooke

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

After myocardial injury, the cardiac muscle does not regenerate and heals by forming a scar. This process results in loss of heart function and ultimately heart failure. Recent application of reprogramming technology, where forced expression of master regulators convert scar-forming cells to become cardiovascular cells in vivo, has fueled new hope for the development of therapies targeting heart disease.

Original language	English (US)
Pages (from-to)	210-212
Number of pages	3
Journal	Methodist DeBakey cardiovascular journal
Volume	9
Issue number	4
DOIs	https://doi.org/10.14797/mdcj-9-4-210
State	Published - 2013

Keywords

cardiomyocytes
cardiovascular diseases
cardiovascular regeneration
transdifferentiation
transflammation

ASJC Scopus subject areas

General Medicine

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10.14797/mdcj-9-4-210

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abstract = "After myocardial injury, the cardiac muscle does not regenerate and heals by forming a scar. This process results in loss of heart function and ultimately heart failure. Recent application of reprogramming technology, where forced expression of master regulators convert scar-forming cells to become cardiovascular cells in vivo, has fueled new hope for the development of therapies targeting heart disease. ",

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AU - Cooke, John P.

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AB - After myocardial injury, the cardiac muscle does not regenerate and heals by forming a scar. This process results in loss of heart function and ultimately heart failure. Recent application of reprogramming technology, where forced expression of master regulators convert scar-forming cells to become cardiovascular cells in vivo, has fueled new hope for the development of therapies targeting heart disease.

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KW - cardiovascular regeneration

KW - transdifferentiation

KW - transflammation

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Therapeutic transdifferentiation: can we generate cardiac tissue rather than scar after myocardial injury?

Abstract

Keywords

ASJC Scopus subject areas

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