Therapeutic transdifferentiation: can we generate cardiac tissue rather than scar after myocardial injury?

Nazish Sayed, Wing T.ak Wong, John P. Cooke

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

After myocardial injury, the cardiac muscle does not regenerate and heals by forming a scar. This process results in loss of heart function and ultimately heart failure. Recent application of reprogramming technology, where forced expression of master regulators convert scar-forming cells to become cardiovascular cells in vivo, has fueled new hope for the development of therapies targeting heart disease.

Original languageEnglish (US)
Pages (from-to)210-212
Number of pages3
JournalMethodist DeBakey cardiovascular journal
Volume9
Issue number4
DOIs
StatePublished - 2013

Keywords

  • cardiomyocytes
  • cardiovascular diseases
  • cardiovascular regeneration
  • transdifferentiation
  • transflammation

ASJC Scopus subject areas

  • Medicine(all)

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