TY - JOUR
T1 - Therapeutic Transdifferentiation
T2 - A Novel Approach for Ischemic Syndromes
AU - Connell, Jennifer P.
AU - Kodali, Santhisri
AU - Cooke, John P.
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2015/7/1
Y1 - 2015/7/1
N2 - The technological development of induced pluripotent stem cells (iPSCs) has overcome many of the limitations of adult and embryonic stem cells. We have found that activation of innate immunity signaling is necessary for this process, as it facilitates epigenetic plasticity in cells by a process called transflammation. More recently, we have discovered that transflammation also facilitates the transdifferentiation of cells directly from one somatic cell type to another. This insight may lead to a promising therapeutic pathway that avoids reverting cells all the way back to pluripotency before achieving a cell type of interest. While there is much therapeutic promise to transflammation and transdifferentiation, there is also evidence that transdifferentiation plays a role in some pathological conditions, including atherosclerosis. Ultimately, better understanding of transflammation will facilitate the development of regenerative therapies.
AB - The technological development of induced pluripotent stem cells (iPSCs) has overcome many of the limitations of adult and embryonic stem cells. We have found that activation of innate immunity signaling is necessary for this process, as it facilitates epigenetic plasticity in cells by a process called transflammation. More recently, we have discovered that transflammation also facilitates the transdifferentiation of cells directly from one somatic cell type to another. This insight may lead to a promising therapeutic pathway that avoids reverting cells all the way back to pluripotency before achieving a cell type of interest. While there is much therapeutic promise to transflammation and transdifferentiation, there is also evidence that transdifferentiation plays a role in some pathological conditions, including atherosclerosis. Ultimately, better understanding of transflammation will facilitate the development of regenerative therapies.
KW - epigenetic plasticity
KW - induced pluripotent stem cells
KW - innate immunity
KW - transdifferentiation
KW - transflammation
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U2 - 10.14797/mdcj-11-3-176
DO - 10.14797/mdcj-11-3-176
M3 - Review article
C2 - 26634026
AN - SCOPUS:85021858173
VL - 11
SP - 176
EP - 180
JO - Methodist DeBakey cardiovascular journal
JF - Methodist DeBakey cardiovascular journal
SN - 1947-6094
IS - 3
ER -