TY - JOUR
T1 - Therapeutic synthetic polymers
T2 - A game of Russian roulette?
AU - Hunter, A. Christy
AU - Moghimi, Seyed
PY - 2002/10/1
Y1 - 2002/10/1
N2 - Synthetic polymer-based drug-delivery systems have been applied in drug delivery for the past 50 years. So why are there so few examples of these macromolecules being used successfully in the clinic? It is our view that many products are failing because of a neglect of the fundamental science surrounding the architectural control of the molecules present, their behaviour following in vivo administration and host response. Adverse events following parenteral administration of approved synthetic polymer-based systems have resulted in unpredictable and fatal responses in a significant number of individuals. Acceptance of the importance of immunotoxicological factors in response to the presence of these macromolecules must be addressed if emergent technologies, such as polymer-based gene-delivery systems, are going to succeed.
AB - Synthetic polymer-based drug-delivery systems have been applied in drug delivery for the past 50 years. So why are there so few examples of these macromolecules being used successfully in the clinic? It is our view that many products are failing because of a neglect of the fundamental science surrounding the architectural control of the molecules present, their behaviour following in vivo administration and host response. Adverse events following parenteral administration of approved synthetic polymer-based systems have resulted in unpredictable and fatal responses in a significant number of individuals. Acceptance of the importance of immunotoxicological factors in response to the presence of these macromolecules must be addressed if emergent technologies, such as polymer-based gene-delivery systems, are going to succeed.
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U2 - 10.1016/S1359-6446(02)02444-3
DO - 10.1016/S1359-6446(02)02444-3
M3 - Review article
C2 - 12546917
AN - SCOPUS:0036808041
VL - 7
SP - 998
EP - 1001
JO - Drug Discovery Today
JF - Drug Discovery Today
SN - 1359-6446
IS - 19
ER -