Therapeutic strategies for harnessing human eosinophils in allergic inflammation, hypereosinophilic disorders, and cancer

Zhaleh J. Amini-Vaughan, Margarita Martinez-Moczygemba, David P. Huston

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The eosinophil is a multifunctional granulocyte best known for providing host defense against parasites. Paradoxically, eosinophils are also implicated in the pathogenesis of allergic inflammation, asthma, and hypereosinophilic syndromes. Emerging evidence also supports the potential for harnessing the cytotoxic power of eosinophils and redirecting it to kill solid tumors. Central to eosinophil physiology is interleukin-5 (IL-5) and its receptor (IL-5R) which is composed of a ligand-specific alpha chain (IL-5Rα) and the common beta chain (βc). Eosinophil activation can lead to their degranulation, resulting in rapid release of an arsenal of tissue-destructive proinflammatory mediators and cytotoxic proteins that can be both beneficial and detrimental to the host. This review discusses eosinophil immunobiology and therapeutic strategies for targeting of IL-5 and IL-5R, as well as the potential for harnessing eosinophil cytotoxicity as a tumoricide.

Original languageEnglish (US)
Pages (from-to)402-412
Number of pages11
JournalCurrent Allergy and Asthma Reports
Volume12
Issue number5
DOIs
StatePublished - Oct 2012

Keywords

  • Allergic inflammation
  • Anti-IL-5 antibodies
  • Anti-IL-5R antibodies
  • Asthma
  • Cancer
  • Eosinophil
  • Eosinophilic syndromes
  • Hypereosinophilic disorders
  • IL-5 receptor (IL-5R)
  • Interleukin-5 (IL-5)
  • Therapeutic
  • Treatment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

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