Therapeutic Nanoparticles Based on Curcumin and Bamboo Charcoal Nanoparticles for Chemo-Photothermal Synergistic Treatment of Cancer and Radioprotection of Normal Cells

Jiani Xie, Yuan Yong, Xinghua Dong, Jiangfeng Du, Zhao Guo, Linji Gong, Shuang Zhu, Gan Tian, Shicang Yu, Zhanjun Gu, Yuliang Zhao

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Low water solubility, extensive metabolism, and drug resistance are the existing unavoidable disadvantages of the insoluble drug curcumin in biomedical applications. Herein, we employed d-α-tocopherol polyethylene glycol 1000 succinate (TPGS)-functionalized near-infrared (NIR)-triggered photothermal mesoporous nanocarriers with bamboo charcoal nanoparticles (TPGS-BCNPs) to load and deliver curcumin for improving its bioavailability. This system could considerably increase the accumulation of curcumin in cancer cells for enhanced curcumin bioavailability via simultaneously promoting the cellular internalization of the as-synthesized composite (TPGS-BCNPs@curcumin) by the size effect of NPs and considerably triggering controlled curcumin release from TPGS-BCNPs@curcumin by NIR stimulation and reducing efflux of curcumin by the P-glycoprotein (P-gp) inhibition of TPGS, so as to enhance the therapeutic effect of curcumin and realize a better chemo-photothermal synergetic therapy in vitro and in vivo. Besides cancer therapy, studies indicated that curcumin and some carbon materials could be used as radical scavengers that play an important role in the radioprotection of normal cells. Hence, we also investigated the free-radical-scavenging ability of the TPGS-BCNPs@curcumin composite in vitro to preliminarily evaluate its radioprotection ability for healthy tissues. Therefore, our work provides a multifunctional delivery system for curcumin bioavailability enhancement, chemo-photothermal synergetic therapy of cancer, and radioprotection of healthy tissues.

Original languageEnglish (US)
Pages (from-to)14281-14291
Number of pages11
JournalACS Applied Materials and Interfaces
Volume9
Issue number16
DOIs
StatePublished - Apr 26 2017

Keywords

  • bamboo charcoal nanoparticles
  • bioavailability
  • chemotherapy
  • curcumin
  • photothermal therapy
  • radioprotection

ASJC Scopus subject areas

  • Materials Science(all)

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