Therapeutic mRNA delivery to leukocytes

Yasmin Granot-Matok, Edo Kon, Niels Dammes, Gilad Mechtinger, Dan Peer

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


In the past few years mRNA molecules have become an attractive class of new drugs with numerous opportunities. mRNA therapeutics holds great potential for the treatment of a variety of diseases and is an emerging field both in academia and in the pharma industry. Among the various mRNA-based therapeutic approaches, immunotherapy is one of the pioneering and most advanced therapy to date. Immune cells manipulation using mRNA is commonly used for vaccination purposes, but its potential is much broader. In this review, we discuss the promise of mRNA delivery to leukocytes. We aim to provide an overview of the main progress in this field, as well as the challenges in expanding the scope of mRNA therapy for different therapeutic applications. We also discuss the main technological developments for overcoming mRNA therapy limitations, including mRNA rational design and delivery platforms.

Original languageEnglish (US)
Pages (from-to)165-175
Number of pages11
JournalJournal of Controlled Release
StatePublished - Jul 10 2019

ASJC Scopus subject areas

  • Pharmaceutical Science


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