Therapeutic drug monitoring of cerebrospinal fluid vancomycin concentration during intraventricular administration

D. Popa; L. Loewenstein; S. W. Lam; E. A. Neuner; C. L. Ahrens; A. Bhimraj

doi:10.1016/j.jhin.2015.10.017

Therapeutic drug monitoring of cerebrospinal fluid vancomycin concentration during intraventricular administration

D. Popa, L. Loewenstein, S. W. Lam, E. A. Neuner, C. L. Ahrens, A. Bhimraj

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Limited data are available on intraventricular vancomycin dosing for meningitis. This study explored clinical characteristics that correlated with cerebrospinal fluid (CSF) concentrations. Over a nine-year period, 13 patients with 34 CSF vancomycin concentrations were evaluated. CSF output and time from dose correlated with CSF vancomycin concentration. No relationship was seen with regards to CSF protein, white blood cell count or glucose.

Original language	English (US)
Pages (from-to)	199-202
Number of pages	4
Journal	Journal of Hospital Infection
Volume	92
Issue number	2
DOIs	https://doi.org/10.1016/j.jhin.2015.10.017
State	Published - Feb 1 2016

Keywords

Intraventricular
Meningitis
Therapeutic drug monitoring
Vancomycin
Ventriculitis

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.jhin.2015.10.017

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title = "Therapeutic drug monitoring of cerebrospinal fluid vancomycin concentration during intraventricular administration",

abstract = "Limited data are available on intraventricular vancomycin dosing for meningitis. This study explored clinical characteristics that correlated with cerebrospinal fluid (CSF) concentrations. Over a nine-year period, 13 patients with 34 CSF vancomycin concentrations were evaluated. CSF output and time from dose correlated with CSF vancomycin concentration. No relationship was seen with regards to CSF protein, white blood cell count or glucose.",

keywords = "Intraventricular, Meningitis, Therapeutic drug monitoring, Vancomycin, Ventriculitis",

author = "D. Popa and L. Loewenstein and Lam, \{S. W.\} and Neuner, \{E. A.\} and Ahrens, \{C. L.\} and A. Bhimraj",

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T1 - Therapeutic drug monitoring of cerebrospinal fluid vancomycin concentration during intraventricular administration

AU - Popa, D.

AU - Loewenstein, L.

AU - Lam, S. W.

AU - Neuner, E. A.

AU - Ahrens, C. L.

AU - Bhimraj, A.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Limited data are available on intraventricular vancomycin dosing for meningitis. This study explored clinical characteristics that correlated with cerebrospinal fluid (CSF) concentrations. Over a nine-year period, 13 patients with 34 CSF vancomycin concentrations were evaluated. CSF output and time from dose correlated with CSF vancomycin concentration. No relationship was seen with regards to CSF protein, white blood cell count or glucose.

AB - Limited data are available on intraventricular vancomycin dosing for meningitis. This study explored clinical characteristics that correlated with cerebrospinal fluid (CSF) concentrations. Over a nine-year period, 13 patients with 34 CSF vancomycin concentrations were evaluated. CSF output and time from dose correlated with CSF vancomycin concentration. No relationship was seen with regards to CSF protein, white blood cell count or glucose.

KW - Intraventricular

KW - Meningitis

KW - Therapeutic drug monitoring

KW - Vancomycin

KW - Ventriculitis

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JO - Journal of Hospital Infection

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IS - 2

ER -

Therapeutic drug monitoring of cerebrospinal fluid vancomycin concentration during intraventricular administration

Abstract

Keywords

ASJC Scopus subject areas

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