TY - CHAP
T1 - Therapeutic Cloning and Tissue Engineering
AU - Koh, Chester J.
AU - Atala, Anthony
PY - 2004/12/1
Y1 - 2004/12/1
N2 - A severe shortage of donor organs available for transplantation in the United States leaves patients suffering from diseased and injured organs with few treatment options. Scientists in the field of tissue engineering apply the principles of cell transplantation, material science, and engineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The present chapter reviews recent advances that have occurred in therapeutic cloning and tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.
AB - A severe shortage of donor organs available for transplantation in the United States leaves patients suffering from diseased and injured organs with few treatment options. Scientists in the field of tissue engineering apply the principles of cell transplantation, material science, and engineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Therapeutic cloning, where the nucleus from a donor cell is transferred into an enucleated oocyte in order to extract pluripotent embryonic stem cells, offers a potentially limitless source of cells for tissue engineering applications. The present chapter reviews recent advances that have occurred in therapeutic cloning and tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure.
UR - http://www.scopus.com/inward/record.url?scp=2642576663&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2642576663&partnerID=8YFLogxK
U2 - 10.1016/S0070-2153(04)60001-9
DO - 10.1016/S0070-2153(04)60001-9
M3 - Chapter
C2 - 15094294
AN - SCOPUS:2642576663
SN - 0121531600
SN - 9780121531607
T3 - Current Topics in Developmental Biology
SP - 1
EP - 15
BT - Current Topics in Developmental Biology
ER -