Therapeutic and donor apheresis

Jill Adamski, Tina S. Ipe, Theresa Kinard

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review


Apheresis machines separate whole blood into cellular and plasma fractions. This allows for therapeutic interventions through removal of pathologic substances from these fractions (e.g., therapeutic plasma exchange to remove acetylcholine receptor antibodies in patients with myasthenia gravis) or by isolation and treatment of a specific blood component (e.g., collection and photoactivation of WBCs to induce immunomodulation by extracorporeal photopheresis). Apheresis procedures are also used to collect blood products for transfusion and hematopoietic progenitor cells for transplant. This chapter focuses on the basic principles of apheresis procedures, indications for therapeutic apheresis that are supported by evidence-based guidelines, and the management of adverse events associated with these procedures.

Original languageEnglish (US)
Title of host publicationTransfusion Medicine, Apheresis, and Hemostasis
Subtitle of host publicationReview Questions and Case Studies
EditorsHuy Pham, Lance Williams, III
Number of pages25
ISBN (Electronic)9780128039991
ISBN (Print)9780128040300
StatePublished - Sep 20 2017


  • Citrate toxicity
  • Plasmapheresis
  • Red blood cell exchange
  • Stem cell collection
  • Therapeutic plasma exchange

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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