Theranostic tumor homing nanocarriers for the treatment of lung cancer

Apurva R. Patel, Mahavir B. Chougule, Ed Lim, Kevin P. Francis, Stephen Safe, Mandip Singh

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The drugs/strategies to selectively inhibit tumor blood supply have generated interest in recent years for enhancement of cancer therapeutics. The objective of this study was to formulate tumor homing PEGylated CREKA peptide conjugated theranostic nanoparticles of DIM-C-pPhC6H5 (DIM-P) and investigate in vivo antitumor activity as well as evaluate the targeted efficiency to lung tumors using imaging techniques. DIM-P loaded Nanoparticles (NCs-D) were prepared using lipids, and DOGS-NTA-Ni and the surface of NCs-D were modified with PEGylated CREKA peptide (PCNCs-D). PCNCs-D showed 3 fold higher binding to clotted plasma proteins in tumor vasculature compared to NCs-D. PCNCs-D showed 26%. ±. 4% and 22%. ±. 5% increase in tumor reduction compared to NCs-D in metastatic and orthotopic models respectively. In-vivo imaging studies showed ~. 40 folds higher migration of PCNCs-Di in tumor vasculature than NCs-Di. Our studies demonstrate the role of PCNCs-D as theranostic tumor homing drug delivery and imaging systems for lung cancer diagnosis and treatment. From the Clinical Editor: This study demonstrates a very efficient delivery system to address lung cancer growth through blood supply inhibition.

Original languageEnglish (US)
Pages (from-to)e1053-e1063
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume10
Issue number5
DOIs
StatePublished - Jul 2014

Keywords

  • Cancer treatment
  • In-vivo imaging
  • Nanoparticles
  • Targeted delivery
  • Theranostic
  • Tumor homing

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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