The utility of positron emission tomography in cardiac amyloidosis

Subha Saeed, Jean Michel Saad, Ahmed Ibrahim Ahmed, Yushui Han, Mouaz H. Al-Mallah

Research output: Contribution to journalReview articlepeer-review


Cardiac amyloidosis, characterized by progressive restrictive cardiomyopathy, presents unusual diagnostic challenges. Conventional cardiac scintigraphy has shown limited utility in the quantification of disease burden and serial follow-up of cardiac amyloidosis. The advent of specialized positron emission tomography with specific amyloid-binding radiotracers has the potential to change currently employed diagnostic algorithms for the imaging of cardiac amyloidosis. This review aims to discuss the diagnostic utility of amyloid-binding radiotracers, including Pittsburg compound B, florbetapir, florbetapan, and sodium fluoride. These tracers have promising potential for the early detection of the particular type of cardiac amyloidosis, pursuing relevant medical intervention, assessing amyloid burden, monitoring treatment response, and overall prognostication.

Original languageEnglish (US)
Pages (from-to)1531-1541
Number of pages11
JournalHeart Failure Reviews
Issue number5
StatePublished - Sep 2022


  • Cardiac amyloidosis
  • Cardiac scintigraphy
  • Florbetapan
  • Florbetapir
  • Pittsburg compound B
  • Positron emission tomography
  • Sodium fluoride

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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