TY - JOUR
T1 - The utility of positron emission tomography in cardiac amyloidosis
AU - Saeed, Subha
AU - Saad, Jean Michel
AU - Ahmed, Ahmed Ibrahim
AU - Han, Yushui
AU - Al-Mallah, Mouaz H.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/9
Y1 - 2022/9
N2 - Cardiac amyloidosis, characterized by progressive restrictive cardiomyopathy, presents unusual diagnostic challenges. Conventional cardiac scintigraphy has shown limited utility in the quantification of disease burden and serial follow-up of cardiac amyloidosis. The advent of specialized positron emission tomography with specific amyloid-binding radiotracers has the potential to change currently employed diagnostic algorithms for the imaging of cardiac amyloidosis. This review aims to discuss the diagnostic utility of amyloid-binding radiotracers, including Pittsburg compound B, florbetapir, florbetapan, and sodium fluoride. These tracers have promising potential for the early detection of the particular type of cardiac amyloidosis, pursuing relevant medical intervention, assessing amyloid burden, monitoring treatment response, and overall prognostication.
AB - Cardiac amyloidosis, characterized by progressive restrictive cardiomyopathy, presents unusual diagnostic challenges. Conventional cardiac scintigraphy has shown limited utility in the quantification of disease burden and serial follow-up of cardiac amyloidosis. The advent of specialized positron emission tomography with specific amyloid-binding radiotracers has the potential to change currently employed diagnostic algorithms for the imaging of cardiac amyloidosis. This review aims to discuss the diagnostic utility of amyloid-binding radiotracers, including Pittsburg compound B, florbetapir, florbetapan, and sodium fluoride. These tracers have promising potential for the early detection of the particular type of cardiac amyloidosis, pursuing relevant medical intervention, assessing amyloid burden, monitoring treatment response, and overall prognostication.
KW - Cardiac amyloidosis
KW - Cardiac scintigraphy
KW - Florbetapan
KW - Florbetapir
KW - Pittsburg compound B
KW - Positron emission tomography
KW - Sodium fluoride
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U2 - 10.1007/s10741-021-10183-w
DO - 10.1007/s10741-021-10183-w
M3 - Review article
C2 - 34743267
AN - SCOPUS:85118575513
VL - 27
SP - 1531
EP - 1541
JO - Heart Failure Reviews
JF - Heart Failure Reviews
SN - 1382-4147
IS - 5
ER -