TY - JOUR
T1 - The utility of marginal donors in liver transplantation
AU - Busuttil, Ronald W.
AU - Tanaka, Koichi
N1 - Funding Information:
From the * Department of Surgery, Division of Liver and Pancreas Transplantation, Dumont-UCLA Transplant Center, Los Angeles, CA, and the †Department of Surgery, Kyoto University, Kyoto, Japan. Supported by Fujisawa Healthcare Inc, Japan. Dr. Busuttil is a consultant for Fujisawa Healthcare, Inc. Address reprint requests to Ronald W. Busuttil, MD, PhD, Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, 77-120 CHS, 10833 Le Conte Ave, Los Angeles, CA 90095. Telephone: 310-825-5318; FAX: 310-206-7760; E-mail: [email protected] Copyright © 2003 by the American Association for the Study of Liver Diseases 1527-6465/03/0907-0001$30.00/0 doi:10.1053/jlts.2003.50105
PY - 2003/7/1
Y1 - 2003/7/1
N2 - The shortage of organs has led centers to expand their criteria for the acceptance of marginal donors. The combination of multiple marginal factors seems to be additive on graft injury. In this review, the utility of various marginal donors in patients requiring liver transplantation will be described, including older donors, steatotic livers, non-heart-beating donors, donors with viral hepatitis, and donors with malignancies. The pathophysiology of the marginal donor will be discussed, along with strategies for minimizing the ischemia reperfusion injury experienced by these organs. Finally, new strategies for improving the function of the marginal/expanded donor liver will be reviewed.
AB - The shortage of organs has led centers to expand their criteria for the acceptance of marginal donors. The combination of multiple marginal factors seems to be additive on graft injury. In this review, the utility of various marginal donors in patients requiring liver transplantation will be described, including older donors, steatotic livers, non-heart-beating donors, donors with viral hepatitis, and donors with malignancies. The pathophysiology of the marginal donor will be discussed, along with strategies for minimizing the ischemia reperfusion injury experienced by these organs. Finally, new strategies for improving the function of the marginal/expanded donor liver will be reviewed.
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U2 - 10.1053/jlts.2003.50105
DO - 10.1053/jlts.2003.50105
M3 - Article
C2 - 12827549
AN - SCOPUS:0038487015
SN - 1527-6465
VL - 9
SP - 651
EP - 663
JO - Liver Transplantation
JF - Liver Transplantation
IS - 7
ER -