The use of mouse models for lung cancer chemoprevention studies

Yian Wang, Michael S. You, Lucina C. Rouggly, Ming You

Research output: Chapter in Book/Report/Conference proceedingChapter


Mouse lung tumor models are widely used in lung cancer chemopreventive studies. Lung cancer is a heterogeneous disease histologically classified as small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC), which is usually divided into adenocarcinoma, squamous cell carcinoma (SCC), and large cell carcinoma. In order to illustrate the power of the mouse model in preclinical lung cancer investigations, comprehensive instructions for the selection of mice, genotyping, and induction of lung tumors (e.g., adenoma/adenocarcinoma, lung SCC, and SCLC) in mice are provided. We have described in detail the histological features of these tumors and the application of these features in lung cancer chemoprevention studies. We have also provided detailed information on how to semiquantitatively phenotype lung tumor development. The basic protocol described here could easily be applied to other approaches to lung cancer prevention such as chemoprevention or immunoprevention.

Original languageEnglish (US)
Title of host publicationCancer Prevention
Subtitle of host publicationDietary Factors and Pharmacology
PublisherHumana Press
Number of pages19
ISBN (Print)9781461492269
StatePublished - 2014

Publication series

NameMethods in Pharmacology and Toxicology
ISSN (Print)1557-2153
ISSN (Electronic)1940-6053


  • Adenocarcinoma
  • Animal models
  • Chemoprevention
  • Lung cancer
  • Small-cell lung cancer
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)


Dive into the research topics of 'The use of mouse models for lung cancer chemoprevention studies'. Together they form a unique fingerprint.

Cite this