The use of intensity modulated radiotherapy for the treatment of extensive and recurrent juvenile angiofibroma

Ronald B. Kuppersmith, Bin S. Teh, Donald T. Donovan, Wei Yuan Mai, J. Kam Chiu, Shiao Y. Woo, E. Brian Butler

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

These case series are presented to describe the application and advantages of intensity modulated radiotherapy (IMRT) for the treatment of extensive and/or recurrent juvenile angiofibroma. Two patients were diagnosed with recurrence at 11 and 13 months postoperatively, and one was surgically unresectable. The affected areas included the base of skull, cavernous sinus, pterygopalatine fossa, infratemporal fossa, posterior orbit and nasopharynx. Highly conformal IMRT was delivered with limited radiation doses to the optic nerves, optic chiasm, brainstem, brain, spinal cord, lens, retina, mandible, and parotid. The total dose delivered to the tumor varied from 3400 to 4500 cGy. The tumor shrunk radiographically in all three cases and there was no endoscopic evidence of disease in two cases at 15 months and 40 months. There was no acute toxicity. Late toxicity was limited to one episode of epistaxis and persistent rhinitis in one patient. In conclusion, IMRT provides several advantages over conventional radiotherapy in the treatment of recurrent juvenile angiofibroma. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)261-268
Number of pages8
JournalInternational Journal of Pediatric Otorhinolaryngology
Volume52
Issue number3
DOIs
StatePublished - May 30 2000

Keywords

  • Computer-assisted treatment planning
  • Intensity modulation
  • Juvenile angiofibroma
  • Radiotherapy

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine
  • Surgery

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