TY - JOUR
T1 - The use of intensity modulated radiotherapy for the treatment of extensive and recurrent juvenile angiofibroma
AU - Kuppersmith, Ronald B.
AU - Teh, Bin S.
AU - Donovan, Donald T.
AU - Mai, Wei Yuan
AU - Chiu, J. Kam
AU - Woo, Shiao Y.
AU - Butler, E. Brian
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2000/5/30
Y1 - 2000/5/30
N2 - These case series are presented to describe the application and advantages of intensity modulated radiotherapy (IMRT) for the treatment of extensive and/or recurrent juvenile angiofibroma. Two patients were diagnosed with recurrence at 11 and 13 months postoperatively, and one was surgically unresectable. The affected areas included the base of skull, cavernous sinus, pterygopalatine fossa, infratemporal fossa, posterior orbit and nasopharynx. Highly conformal IMRT was delivered with limited radiation doses to the optic nerves, optic chiasm, brainstem, brain, spinal cord, lens, retina, mandible, and parotid. The total dose delivered to the tumor varied from 3400 to 4500 cGy. The tumor shrunk radiographically in all three cases and there was no endoscopic evidence of disease in two cases at 15 months and 40 months. There was no acute toxicity. Late toxicity was limited to one episode of epistaxis and persistent rhinitis in one patient. In conclusion, IMRT provides several advantages over conventional radiotherapy in the treatment of recurrent juvenile angiofibroma. (C) 2000 Elsevier Science Ireland Ltd.
AB - These case series are presented to describe the application and advantages of intensity modulated radiotherapy (IMRT) for the treatment of extensive and/or recurrent juvenile angiofibroma. Two patients were diagnosed with recurrence at 11 and 13 months postoperatively, and one was surgically unresectable. The affected areas included the base of skull, cavernous sinus, pterygopalatine fossa, infratemporal fossa, posterior orbit and nasopharynx. Highly conformal IMRT was delivered with limited radiation doses to the optic nerves, optic chiasm, brainstem, brain, spinal cord, lens, retina, mandible, and parotid. The total dose delivered to the tumor varied from 3400 to 4500 cGy. The tumor shrunk radiographically in all three cases and there was no endoscopic evidence of disease in two cases at 15 months and 40 months. There was no acute toxicity. Late toxicity was limited to one episode of epistaxis and persistent rhinitis in one patient. In conclusion, IMRT provides several advantages over conventional radiotherapy in the treatment of recurrent juvenile angiofibroma. (C) 2000 Elsevier Science Ireland Ltd.
KW - Computer-assisted treatment planning
KW - Intensity modulation
KW - Juvenile angiofibroma
KW - Radiotherapy
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U2 - 10.1016/S0165-5876(00)00297-4
DO - 10.1016/S0165-5876(00)00297-4
M3 - Article
C2 - 10841956
AN - SCOPUS:0034732897
SN - 0165-5876
VL - 52
SP - 261
EP - 268
JO - International Journal of Pediatric Otorhinolaryngology
JF - International Journal of Pediatric Otorhinolaryngology
IS - 3
ER -