The Underlying Function and Structural Organization of the Intracellular Protein Corona on Graphdiyne Oxide Nanosheet for Local Immunomodulation

Mengyu Guo, Lina Zhao, Jing Liu, Xiaofeng Wang, Haodong Yao, Xueling Chang, Ying Liu, Jiaming Liu, Min You, Jiayu Ren, Fuhui Wang, Liming Wang, Yaling Wang, Huibiao Liu, Yuliang Li, Yuliang Zhao, Rong Cai, Chunying Chen

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Nanomaterial-biology interaction is the critical step in the fate of biomedical nanomedicines, influencing the consequent biological outcomes. Herein, we present two-dimensional carbon-based nanomaterials-graphdiyne oxide (GDYO) nanosheets that interact with an intracellular protein corona consisting of signal transducer and activator of transcription 3 (STAT3), inducing the reeducation of immunosuppressive macrophages. The interaction at the GDYO-STAT3 interface, driven by structure matching, hydrogen bonding, and salt bridges, simultaneously triggers the immune response in the tumor microenvironment, facilitating cancer immunotherapy. For the first time, our data reveal an interaction mechanism between the nanoparticle-protein interfaces inevitably formed inside the cells that determines the macrophage phenotype. Our results suggest that GDYO nanosheets could be applied for local immunomodulation due to their function and structural organization of the intracellular protein corona occurred inside macrophages.

Original languageEnglish (US)
Pages (from-to)6005-6013
Number of pages9
JournalNano Letters
Volume21
Issue number14
DOIs
StatePublished - Jul 28 2021

Keywords

  • GDYO nanosheet
  • intracellular protein corona
  • macrophage polarization
  • tumor immunotherapy

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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