The two-stage standard: Res ipsa loquitur

Hayden N. Box, Timothy S. Brown, Michael H. Huo, Richard E. Jones

Research output: Contribution to journalArticlepeer-review


Periprosthetic joint infection is a morbid and costly complication of total knee arthroplasty. Treatment options vary depending on chronicity of the infection, causative organism, and host factors. Some authors advocate single-stage exchange arthroplasty to decrease patient morbidity and healthcare utilization costs. Due to its proven efficacy for infection eradication and soft tissue healing, however, two-stage exchange arthroplasty remains the gold standard for treatment of periprosthetic joint infection after total knee arthroplasty. In this review, we present the technique of two-stage exchange arthroplasty and evidence supporting its use.

Original languageEnglish (US)
Pages (from-to)84-90
Number of pages7
JournalSeminars in Arthroplasty
Issue number2
StatePublished - Jun 1 2015


  • Periprosthetic joint infection
  • Revision arthroplasty
  • Revision knee arthroplasty
  • Total knee arthroplasty
  • Two-stage revision arthroplasty

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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