The transport of nanoparticles in blood vessels: The effect of vessel permeability and blood rheology

Francesco Gentile, Mauro Ferrari, Paolo Decuzzi

Research output: Contribution to journalArticle

125 Scopus citations

Abstract

The longitudinal transport of nanoparticles in blood vessels has been analyzed with blood described as a Casson fluid. Starting from the celebrated Taylor and Aris theory, an explicit expression has been derived for the effective longitudinal diffusion (D eff) depending non-linearly on the rheological parameter ξc, the ratio between the plug and the vessel radii; and on the permeability parameters related to the hydraulic conductivity and pressure drop across the vessel wall, respectively. An increase of ξc or has the effect of reducing D eff, and thus both the rheology of blood and the permeability of the vessels may constitute a physiological barrier to the intravascular delivery of nanoparticles.

Original languageEnglish (US)
Pages (from-to)254-261
Number of pages8
JournalAnnals of Biomedical Engineering
Volume36
Issue number2
DOIs
StatePublished - Feb 2008

Keywords

  • Casson fluid
  • Microcirculation
  • Nanoparticles
  • Transport equation

ASJC Scopus subject areas

  • Biomedical Engineering

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