The transport of nanoparticles in blood vessels: The effect of vessel permeability and blood rheology

Francesco Gentile; Mauro Ferrari; Paolo Decuzzi

doi:10.1007/s10439-007-9423-6

The transport of nanoparticles in blood vessels: The effect of vessel permeability and blood rheology

Francesco Gentile, Mauro Ferrari, Paolo Decuzzi

Houston Methodist Hospital

Research output: Contribution to journal › Article › peer-review

153 Scopus citations

Abstract

The longitudinal transport of nanoparticles in blood vessels has been analyzed with blood described as a Casson fluid. Starting from the celebrated Taylor and Aris theory, an explicit expression has been derived for the effective longitudinal diffusion (D _eff) depending non-linearly on the rheological parameter ξ_c, the ratio between the plug and the vessel radii; and on the permeability parameters related to the hydraulic conductivity and pressure drop across the vessel wall, respectively. An increase of ξ_c or has the effect of reducing D _eff, and thus both the rheology of blood and the permeability of the vessels may constitute a physiological barrier to the intravascular delivery of nanoparticles.

Original language	English (US)
Pages (from-to)	254-261
Number of pages	8
Journal	Annals of Biomedical Engineering
Volume	36
Issue number	2
DOIs	https://doi.org/10.1007/s10439-007-9423-6
State	Published - Feb 2008

Keywords

Casson fluid
Microcirculation
Nanoparticles
Transport equation

ASJC Scopus subject areas

Biomedical Engineering

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10.1007/s10439-007-9423-6

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abstract = "The longitudinal transport of nanoparticles in blood vessels has been analyzed with blood described as a Casson fluid. Starting from the celebrated Taylor and Aris theory, an explicit expression has been derived for the effective longitudinal diffusion (D eff) depending non-linearly on the rheological parameter ξc, the ratio between the plug and the vessel radii; and on the permeability parameters related to the hydraulic conductivity and pressure drop across the vessel wall, respectively. An increase of ξc or has the effect of reducing D eff, and thus both the rheology of blood and the permeability of the vessels may constitute a physiological barrier to the intravascular delivery of nanoparticles.",

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AB - The longitudinal transport of nanoparticles in blood vessels has been analyzed with blood described as a Casson fluid. Starting from the celebrated Taylor and Aris theory, an explicit expression has been derived for the effective longitudinal diffusion (D eff) depending non-linearly on the rheological parameter ξc, the ratio between the plug and the vessel radii; and on the permeability parameters related to the hydraulic conductivity and pressure drop across the vessel wall, respectively. An increase of ξc or has the effect of reducing D eff, and thus both the rheology of blood and the permeability of the vessels may constitute a physiological barrier to the intravascular delivery of nanoparticles.

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KW - Microcirculation

KW - Nanoparticles

KW - Transport equation

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The transport of nanoparticles in blood vessels: The effect of vessel permeability and blood rheology

Abstract

Keywords

ASJC Scopus subject areas

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