The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development

Yong Yu, Cui Wang, Simon Clare, Juexuan Wang, Song Choon Lee, Cordelia Brandt, Shannon Burke, Liming Lu, Daqian He, Nancy A. Jenkins, Neal G. Copeland, Gordon Dougan, Pentao Liu

Research output: Contribution to journalArticle

98 Scopus citations

Abstract

Group 2 innate lymphoid cells (ILCs), or ILC2s, are a subset of recently identified ILCs, which play important roles in innate immunity by producing type 2 effector cytokines. Several transcription factors have been found to have critical functions in the development of both ILC2s and T cells. We report here that Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the ILC2 lineage and is required for ILC2 development. The Bcl11b gene is expressed in ∼28% of ILC progenitors (ILCPs; common helper innate lymphoid progenitors or ILCPs expressing either ID2 or promyelocytic leukemia zinc finger, respectively). Both in vitro and in vivo, these Bcl11b-expressing early ILCPs generate only ILC2s. Inactivation of Bcl11b causes a complete loss of ILC2 development from hematopoietic progenitors, which is confirmed upon immune challenge with either papain administration or influenza virus infection.

Original languageEnglish (US)
Pages (from-to)865-74
Number of pages10
JournalThe Journal of experimental medicine
Volume212
Issue number6
DOIs
StatePublished - Jun 1 2015

Keywords

  • Animals
  • Cell Lineage
  • Cell Separation
  • Chromatin Immunoprecipitation
  • Female
  • Flow Cytometry
  • GATA3 Transcription Factor
  • Gene Deletion
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Genes, Reporter
  • Hematopoietic Stem Cells
  • Immunity, Innate
  • Inducible T-Cell Co-Stimulator Protein
  • Lymphocytes
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Receptors, Interleukin
  • Repressor Proteins
  • Tumor Suppressor Proteins
  • Zinc Fingers

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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