TY - JOUR
T1 - The therapeutic potential of targeting the CHD protein family in cancer
AU - Zhang, Min
AU - Wu, Kaiyuan
AU - Zhang, Weijie
AU - Lin, Xia
AU - Cao, Qi
AU - Zhang, Lili
AU - Chen, Kaifu
N1 - Publisher Copyright:
© 2024 Elsevier Inc.
PY - 2024/4
Y1 - 2024/4
N2 - Accumulating evidence indicates that epigenetic events undergo deregulation in various cancer types, playing crucial roles in tumor development. Among the epigenetic factors involved in the epigenetic remodeling of chromatin, the chromodomain helicase DNA-binding protein (CHD) family frequently exhibits gain- or loss-of-function mutations in distinct cancer types. Therefore, targeting CHD remodelers holds the potential for antitumor treatment. In this review, we discuss epigenetic regulations of cancer development. We emphasize proteins in the CHD family, delving deeply into the intricate mechanisms governing their functions. Additionally, we provide an overview of current therapeutic strategies targeting CHD family members in preclinical trials. We further discuss the promising approaches that have demonstrated early signs of success in cancer treatment.
AB - Accumulating evidence indicates that epigenetic events undergo deregulation in various cancer types, playing crucial roles in tumor development. Among the epigenetic factors involved in the epigenetic remodeling of chromatin, the chromodomain helicase DNA-binding protein (CHD) family frequently exhibits gain- or loss-of-function mutations in distinct cancer types. Therefore, targeting CHD remodelers holds the potential for antitumor treatment. In this review, we discuss epigenetic regulations of cancer development. We emphasize proteins in the CHD family, delving deeply into the intricate mechanisms governing their functions. Additionally, we provide an overview of current therapeutic strategies targeting CHD family members in preclinical trials. We further discuss the promising approaches that have demonstrated early signs of success in cancer treatment.
KW - Cancer development
KW - Chromatin remodeling
KW - Epigenetic regulation
KW - Therapeutic strategies
UR - http://www.scopus.com/inward/record.url?scp=85186526065&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85186526065&partnerID=8YFLogxK
U2 - 10.1016/j.pharmthera.2024.108610
DO - 10.1016/j.pharmthera.2024.108610
M3 - Review article
C2 - 38367868
AN - SCOPUS:85186526065
SN - 0163-7258
VL - 256
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
M1 - 108610
ER -