The temperature-sensitive role of Cryptococcus neoformans ROM2 in cell morphogenesis

Beth Burgwyn Fuchs, Robin J. Tang, Eleftherios Mylonakis

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


ROM2 is associated with Cryptococcus neoformants virulence. We examined additional roles of ROM2 in C. neoformans and found that ROM2 plays a role in several cell functions specifically at high temperature conditions. Morphologically rom2 mutant cells demonstrated a "tear"-like shape and clustered together. A sub-population of cells had a hyperelongated phenotype at restrictive growth conditions. Altered morphology was associated with defects in actin that was concentrated at the cell periphery and with abnormalities in microtubule organization. Interestingly, the ROM2 associated defects in cell morphology, location of nuclei, and actin and microtubule organization were not observed in cells grown at temperatures below 37°C. These results indicate that in C. neoformans, ROM2 is important at restrictive temperature conditions and is involved in several cell maintenance functions.

Original languageEnglish (US)
Article numbere368
JournalPLoS ONE
Issue number4
StatePublished - Apr 11 2007

ASJC Scopus subject areas

  • General


Dive into the research topics of 'The temperature-sensitive role of Cryptococcus neoformans ROM2 in cell morphogenesis'. Together they form a unique fingerprint.

Cite this