The t(9;22) translocation in philadelphia-positive essential thrombocythaemia does not involve the T lymphocyte lineage

P. J. Browett, H. E. Heslop, A. B. Mehta, J. D. Norton

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

A 42-year-old woman presented with clinical and haematological features of essential thrombocythaemia (ET). Cytogenetic investigation revealed a standard t(9;22) Philadelphia translocation in all evaluable metaphases which persisted throughout treatment. Gene probe analysis of the chromosome 22 breakpoint cluster region (bcr) locus revealed a breakpoint mapping between exons 1 and 3 of the bcr gene, consistent with a standard bcr-abl translocation as found in chronic myeloid leukaemia (CML). Moreover, in separate cell populations, the bcr breakpoint was demonstrable in DNA from granulocytes but not in T cells from either peripheral blood or bone marrow. Since ET is known to be a clonal disorder with a multipotential stem cell origin, these findings suggest that, as in CML, the bcr-abl hybrid gene arises through translocation in a multi-lineage stem cell which does not involve the T lymphocyte lineage.

Original languageEnglish (US)
Pages (from-to)203-205
Number of pages3
JournalActa Haematologica
Volume83
Issue number4
DOIs
StatePublished - 1990

Keywords

  • Breakpoint cluster region
  • Essential thrombocythaemia
  • Philadelphia chromosome
  • T cells

ASJC Scopus subject areas

  • Hematology

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