The strong MRI relaxivity of paramagnetic nanoparticles

Gengmei Xing, Hui Yuan, Rui He, Xueyun Gao, Long Jing, Feng Zhao, Zhifang Chai, Yuliang Zhao

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


We developed a method to synthesize paramagnetic nanoparticles of Gd@C 82(OH)22±2. Such nanoparticles are with ordered microstructures and have strong MRI proton relaxation in vitro/vivo. Compared with commercial Gd-DTPA, a 12× MRI relaxivity of Gd@C82(OH) 22±2 nanoparticles with ordered microstructures was achieved in vitro. The small Gd@C82(OH)22±2 nanoparticles, ∼65nm, could easily escape the RES uptake in vivo; this opens the door for their clinical applications.

Original languageEnglish (US)
Pages (from-to)6288-6291
Number of pages4
JournalJournal of Physical Chemistry B
Issue number20
StatePublished - May 22 2008

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry


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