We developed a method to synthesize paramagnetic nanoparticles of Gd@C 82(OH)22±2. Such nanoparticles are with ordered microstructures and have strong MRI proton relaxation in vitro/vivo. Compared with commercial Gd-DTPA, a 12× MRI relaxivity of Gd@C82(OH) 22±2 nanoparticles with ordered microstructures was achieved in vitro. The small Gd@C82(OH)22±2 nanoparticles, ∼65nm, could easily escape the RES uptake in vivo; this opens the door for their clinical applications.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Surfaces, Coatings and Films
- Materials Chemistry