The strong MRI relaxivity of paramagnetic nanoparticles

Gengmei Xing; Hui Yuan; Rui He; Xueyun Gao; Long Jing; Feng Zhao; Zhifang Chai; Yuliang Zhao

doi:10.1021/jp8012706

The strong MRI relaxivity of paramagnetic nanoparticles

Gengmei Xing, Hui Yuan, Rui He, Xueyun Gao, Long Jing, Feng Zhao, Zhifang Chai, Yuliang Zhao

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

We developed a method to synthesize paramagnetic nanoparticles of Gd@C ₈₂(OH)_22±2. Such nanoparticles are with ordered microstructures and have strong MRI proton relaxation in vitro/vivo. Compared with commercial Gd-DTPA, a 12× MRI relaxivity of Gd@C₈₂(OH) _22±2 nanoparticles with ordered microstructures was achieved in vitro. The small Gd@C₈₂(OH)_22±2 nanoparticles, ∼65nm, could easily escape the RES uptake in vivo; this opens the door for their clinical applications.

Original language	English (US)
Pages (from-to)	6288-6291
Number of pages	4
Journal	Journal of Physical Chemistry B
Volume	112
Issue number	20
DOIs	https://doi.org/10.1021/jp8012706
State	Published - May 22 2008

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Surfaces, Coatings and Films
Materials Chemistry

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10.1021/jp8012706

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T1 - The strong MRI relaxivity of paramagnetic nanoparticles

AU - Xing, Gengmei

AU - Yuan, Hui

AU - He, Rui

AU - Gao, Xueyun

AU - Jing, Long

AU - Zhao, Feng

AU - Chai, Zhifang

AU - Zhao, Yuliang

PY - 2008/5/22

Y1 - 2008/5/22

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AB - We developed a method to synthesize paramagnetic nanoparticles of Gd@C 82(OH)22±2. Such nanoparticles are with ordered microstructures and have strong MRI proton relaxation in vitro/vivo. Compared with commercial Gd-DTPA, a 12× MRI relaxivity of Gd@C82(OH) 22±2 nanoparticles with ordered microstructures was achieved in vitro. The small Gd@C82(OH)22±2 nanoparticles, ∼65nm, could easily escape the RES uptake in vivo; this opens the door for their clinical applications.

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The strong MRI relaxivity of paramagnetic nanoparticles

Abstract

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