TY - JOUR
T1 - The significance of ERK5 catalytic-independent functions in disease pathways
AU - Le, Nhat Tu
N1 - Funding Information:
This study was partially supported by funding from the National Institutes of Health (NIH) to N-TL (HL149303, HL163857, HL134740, and HL157790).
Publisher Copyright:
Copyright © 2023 Le.
PY - 2023
Y1 - 2023
N2 - Extracellular signal-regulated kinase 5 (ERK5), also known as BMK1 or MAPK7, represents a recent addition to the classical mitogen-activated protein kinase (MAPK) family. This family includes well-known members such as ERK1/2, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK), as well as atypical MAPKs such as ERK3, ERK4, ERK7 (ERK8), and Nemo-like kinase (NLK). Comprehensive reviews available elsewhere provide detailed insights into ERK5, which interested readers can refer to for in-depth knowledge (Nithianandarajah-Jones et al., 2012; Monti et al., Cancers (Basel), 2022, 14). The primary aim of this review is to emphasize the essential characteristics of ERK5 and shed light on the intricate nature of its activation, with particular attention to the catalytic-independent functions in disease pathways.
AB - Extracellular signal-regulated kinase 5 (ERK5), also known as BMK1 or MAPK7, represents a recent addition to the classical mitogen-activated protein kinase (MAPK) family. This family includes well-known members such as ERK1/2, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK), as well as atypical MAPKs such as ERK3, ERK4, ERK7 (ERK8), and Nemo-like kinase (NLK). Comprehensive reviews available elsewhere provide detailed insights into ERK5, which interested readers can refer to for in-depth knowledge (Nithianandarajah-Jones et al., 2012; Monti et al., Cancers (Basel), 2022, 14). The primary aim of this review is to emphasize the essential characteristics of ERK5 and shed light on the intricate nature of its activation, with particular attention to the catalytic-independent functions in disease pathways.
KW - ERK5 activation
KW - MAPK
KW - S496 phosphorylation
KW - SAS
KW - SASP
UR - http://www.scopus.com/inward/record.url?scp=85168370965&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85168370965&partnerID=8YFLogxK
U2 - 10.3389/fcell.2023.1235217
DO - 10.3389/fcell.2023.1235217
M3 - Review article
C2 - 37601096
AN - SCOPUS:85168370965
SN - 2296-634X
VL - 11
SP - 1235217
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
M1 - 1235217
ER -