The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging

Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Sahana Suresh Babu, Suresh S. Palaniyandi, Kenichi Watanabe, John P. Cooke, Rajarajan Amirthalingam Thandavarayan

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Because cardiovascular disease remains the major cause of mortality and morbidity world-wide, there remains a compelling need for new insights and novel therapeutic avenues. In this regard, the senescence-accelerated mouse prone 8 (SAMP8) line is a particularly good model for studying the effects of aging on cardiovascular health. Accumulating evidence suggests that this model may shed light on age-associated cardiac and vascular dysfunction and disease. These animals manifest evidence of inflammation, oxidative stress and adverse cardiac remodeling that may recapitulate processes involved in human disease. Early alterations in oxidative damage promote endoplasmic reticulum stress to trigger apoptosis and cytokine production in this genetically susceptible mouse strain. Conversely, pharmacological treatments that reduce inflammation and oxidative stress improve cardiac function in these animals. Therefore, the SAMP8 mouse model provides an exciting opportunity to expand our knowledge of aging in cardiovascular disease and the potential identification of novel targets of treatment. Herein, we review the previous studies performed in SAMP8 mice that provide insight into age-related cardiovascular alterations.

Original languageEnglish (US)
Pages (from-to)291-296
Number of pages6
JournalAgeing Research Reviews
Volume35
DOIs
StatePublished - May 1 2017

Keywords

  • Aging
  • Cardiac remodeling
  • Inflammation
  • Oxidative stress
  • Senescence-accelerated prone mouse 8

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Aging
  • Molecular Biology
  • Neurology

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