The role of transcription factor Pitx3 in dopamine neuron development and Parkinson's disease

Jia Li, John A. Dani, Weidong Le

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

Parkinson's disease (PD) is characterized by the selective loss of dopamine (DA) neurons in the substantia nigra compacta (SNc). The transcription factor Pitx3 is important for the differentiation and maintenance of midbrain DA neurons during development. There is highly restricted and constitutive expression of Pitx3 in the SNc and ventral tegmental area (VTA) of the midbrain after birth. In addition to its importance during development, Pitx3 also has roles in the long-term survival and maintenance of the midbrain DA neurons. In this review, we discuss the function of Pitx3 throughout the life of midbrain neurons and the contribution of Pitx3 to disease mechanisms.

Original languageEnglish (US)
Pages (from-to)855-859
Number of pages5
JournalCurrent Topics in Medicinal Chemistry
Volume9
Issue number10
DOIs
StatePublished - 2009

Keywords

  • Aphakia
  • Mesostriatal
  • Nurr1
  • Parkinsonian
  • Pituitary homeobox
  • Rieg1
  • Substantia nigra
  • Transcription factor 3

ASJC Scopus subject areas

  • Drug Discovery

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