The role of T cell apoptosis in transplantation tolerance

Xian Chang Li, Andrew D. Wells, Terry B. Strom, Laurence A. Turka

Research output: Contribution to journalReview article

65 Scopus citations

Abstract

Rejection of fully MHC-mismatched allografts entails the direct recognition of donor MHC molecules (direct antigen presentation) and the activation of an unusually large mass of alloreactive T cells. There is compelling evidence that apoptotic cell death of activated T cells is a critical initial step in the induction of peripheral allograft tolerance with regimens that are not inherently lymphoablative and that therapies that block T cell activation and T cell apoptosis also block the acquisition of tolerance. Thus, T cell apoptosis may play an important role in reducing the size of cytopathic T cell clones and this process may also promote the development and expansion of immune regulatory cells that are essential in the maintenance of allograft tolerance. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)522-527
Number of pages6
JournalCurrent Opinion in Immunology
Volume12
Issue number5
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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