The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles

P. Decuzzi; Mauro Ferrari

doi:10.1016/j.biomaterials.2007.02.013

The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles

P. Decuzzi, Mauro Ferrari

Houston Methodist Hospital

Research output: Contribution to journal › Article › peer-review

227 Scopus citations

Abstract

The role of specific and non-specific interactions in the receptor-mediated endocytosis of nanoparticles is analyzed. The characteristic time τ_w, the threshold R_th and optimal R_opt radii for particle endocytosis are estimated as a function of the binding energy factor C, bond elasticity factor G, and non-specific attractive/repulsive factor F at the cell-particle interface. It is shown that the contribution of F is as important as that of C and G. General and ready to use formulas are presented that can be a guide in designing nanoparticles with controlled endocytic performances.

Original language	English (US)
Pages (from-to)	2915-2922
Number of pages	8
Journal	Biomaterials
Volume	28
Issue number	18
DOIs	https://doi.org/10.1016/j.biomaterials.2007.02.013
State	Published - Apr 4 2007

Keywords

Bioadhesion
Drug delivery
Nanobiotechnology
Particle internalization
Surface properties

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

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10.1016/j.biomaterials.2007.02.013

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abstract = "The role of specific and non-specific interactions in the receptor-mediated endocytosis of nanoparticles is analyzed. The characteristic time τw, the threshold Rth and optimal Ropt radii for particle endocytosis are estimated as a function of the binding energy factor C, bond elasticity factor G, and non-specific attractive/repulsive factor F at the cell-particle interface. It is shown that the contribution of F is as important as that of C and G. General and ready to use formulas are presented that can be a guide in designing nanoparticles with controlled endocytic performances.",

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AB - The role of specific and non-specific interactions in the receptor-mediated endocytosis of nanoparticles is analyzed. The characteristic time τw, the threshold Rth and optimal Ropt radii for particle endocytosis are estimated as a function of the binding energy factor C, bond elasticity factor G, and non-specific attractive/repulsive factor F at the cell-particle interface. It is shown that the contribution of F is as important as that of C and G. General and ready to use formulas are presented that can be a guide in designing nanoparticles with controlled endocytic performances.

KW - Bioadhesion

KW - Drug delivery

KW - Nanobiotechnology

KW - Particle internalization

KW - Surface properties

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JF - Biomaterials

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ER -

The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

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