The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles

P. Decuzzi, Mauro Ferrari

Research output: Contribution to journalArticle

206 Scopus citations

Abstract

The role of specific and non-specific interactions in the receptor-mediated endocytosis of nanoparticles is analyzed. The characteristic time τw, the threshold Rth and optimal Ropt radii for particle endocytosis are estimated as a function of the binding energy factor C, bond elasticity factor G, and non-specific attractive/repulsive factor F at the cell-particle interface. It is shown that the contribution of F is as important as that of C and G. General and ready to use formulas are presented that can be a guide in designing nanoparticles with controlled endocytic performances.

Original languageEnglish (US)
Pages (from-to)2915-2922
Number of pages8
JournalBiomaterials
Volume28
Issue number18
DOIs
StatePublished - Apr 4 2007

Keywords

  • Bioadhesion
  • Drug delivery
  • Nanobiotechnology
  • Particle internalization
  • Surface properties

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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