The role of recurrent trauma on post-traumatic stress disorder symptoms and substance use among trauma exposed youth

John Leri; Josh M. Cisler; Cody G. Dodd; Shaunna L. Clark; Leslie Taylor; Arrian Theodorou; Anissa Belford; Israel Liberzon; Paul J. Rathouz; D. Jeffrey Newport; Cecilia Devargas; Karen Wagner; Charles B. Nemeroff

doi:10.1016/j.psychres.2024.115980

The role of recurrent trauma on post-traumatic stress disorder symptoms and substance use among trauma exposed youth

John Leri, Josh M. Cisler, Cody G. Dodd, Shaunna L. Clark, Leslie Taylor, Arrian Theodorou, Anissa Belford, Israel Liberzon, Paul J. Rathouz, D. Jeffrey Newport, Cecilia Devargas, Karen Wagner, Charles B. Nemeroff

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Comorbidity between post-traumatic stress disorder (PTSD) and substance use disorder may be explained by a prospective trauma risk conferred by both conditions. The current study modeled concurrent and prospective associations of trauma, PTSD symptoms, and substance use (SU) behavior among trauma exposed youth (ages 8–20). Clinical interviews assessed trauma exposure, PTSD symptom severity, and SU behavior at baseline and at six- and 12-month follow up study visits (N = 2,069). Structural equation models assessed the associations of trauma, PTSD symptoms, and SU behavior. Lifetime trauma was associated with more severe PTSD symptoms and SU behaviors, whereas trauma exposure during the study was only associated with PTSD symptoms. PTSD symptom severity was prospectively associated with trauma exposure. PTSD symptom severity and SU behavior at follow-up study visits were prospectively associated. These results highlight the dynamic interplay between trauma, PTSD symptoms, and SU behavior during youth, a developmental period during which complex psychiatric presentations can have longstanding consequences for health.

Original language	English (US)
Article number	115980
Journal	Psychiatry Research
Volume	338
DOIs	https://doi.org/10.1016/j.psychres.2024.115980
State	Published - Aug 2024

Keywords

Adolescence
Childhood
Childhood trauma research network
Emerging adulthood
PTSD
Stress
Substance use
Texas child mental health care consortium

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2024.115980

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Leri, J., Cisler, J. M., Dodd, C. G., Clark, S. L., Taylor, L., Theodorou, A., Belford, A., Liberzon, I., Rathouz, P. J., Newport, D. J., Devargas, C., Wagner, K., & Nemeroff, C. B. (2024). The role of recurrent trauma on post-traumatic stress disorder symptoms and substance use among trauma exposed youth. Psychiatry Research, 338, Article 115980. https://doi.org/10.1016/j.psychres.2024.115980

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abstract = "Comorbidity between post-traumatic stress disorder (PTSD) and substance use disorder may be explained by a prospective trauma risk conferred by both conditions. The current study modeled concurrent and prospective associations of trauma, PTSD symptoms, and substance use (SU) behavior among trauma exposed youth (ages 8–20). Clinical interviews assessed trauma exposure, PTSD symptom severity, and SU behavior at baseline and at six- and 12-month follow up study visits (N = 2,069). Structural equation models assessed the associations of trauma, PTSD symptoms, and SU behavior. Lifetime trauma was associated with more severe PTSD symptoms and SU behaviors, whereas trauma exposure during the study was only associated with PTSD symptoms. PTSD symptom severity was prospectively associated with trauma exposure. PTSD symptom severity and SU behavior at follow-up study visits were prospectively associated. These results highlight the dynamic interplay between trauma, PTSD symptoms, and SU behavior during youth, a developmental period during which complex psychiatric presentations can have longstanding consequences for health.",

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AU - Liberzon, Israel

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AB - Comorbidity between post-traumatic stress disorder (PTSD) and substance use disorder may be explained by a prospective trauma risk conferred by both conditions. The current study modeled concurrent and prospective associations of trauma, PTSD symptoms, and substance use (SU) behavior among trauma exposed youth (ages 8–20). Clinical interviews assessed trauma exposure, PTSD symptom severity, and SU behavior at baseline and at six- and 12-month follow up study visits (N = 2,069). Structural equation models assessed the associations of trauma, PTSD symptoms, and SU behavior. Lifetime trauma was associated with more severe PTSD symptoms and SU behaviors, whereas trauma exposure during the study was only associated with PTSD symptoms. PTSD symptom severity was prospectively associated with trauma exposure. PTSD symptom severity and SU behavior at follow-up study visits were prospectively associated. These results highlight the dynamic interplay between trauma, PTSD symptoms, and SU behavior during youth, a developmental period during which complex psychiatric presentations can have longstanding consequences for health.

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KW - Substance use

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The role of recurrent trauma on post-traumatic stress disorder symptoms and substance use among trauma exposed youth

Abstract

Keywords

ASJC Scopus subject areas

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