The role of mTOR signalling pathway in hypoxia-induced cognitive impairment

Entesar Yaseen Abdo Qaid, Ninie Nadia Zulkipli, Rahimah Zakaria, Asma Hayati Ahmad, Zahiruddin Othman, Sangu Muthuraju, Teguh Haryo Sasongko

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Hypoxia has been associated with cognitive impairment. Many studies have investigated the role of mTOR signalling pathway in cognitive functions but its role in hypoxia-induced cognitive impairment remains controversial. This review aimed to elucidate the role of mTOR in the mechanisms of cognitive impairment that may pave the way towards the mechanistic understanding and therapeutic intervention of hypoxia-induced cognitive impairment. mTORC1 is normally regulated during mild or acute hypoxic exposure giving rise to neuroprotection, whereas it is overactivated during severe or chronic hypoxia giving rise to neuronal cells death. Thus, it is worth exploring the possibility of maintaining normal mTORC1 activity and thereby preventing cognitive impairment during severe or chronic hypoxia.

Original languageEnglish (US)
Pages (from-to)482-488
Number of pages7
JournalInternational Journal of Neuroscience
Issue number5
StatePublished - 2021


  • BDNF
  • cognitive impairment
  • HIF-1
  • Hypoxia
  • mTORC1
  • mTORC2

ASJC Scopus subject areas

  • Neuroscience(all)


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