Abstract
The identification of tumor antigens has generated a resurgence of interest in immunotherapy for cancer. However, both clinical and animal studies suggest that therapeutic strategies that have mainly focused on the use of CD8+ T cells (and MHC class I-restricted tumor antigens) are not effective in eliminating cancer cells. Recent interest has been directed towards the use of CD4+ T cells in generating antitumor immunity. To this end, the identification of MHC class II-restricted tumor antigens that can stimulate CD4+ T cells might provide opportunities for developing effective cancer vaccines.
Original language | English (US) |
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Pages (from-to) | 269-276 |
Number of pages | 8 |
Journal | Trends in Immunology |
Volume | 22 |
Issue number | 5 |
DOIs | |
State | Published - Aug 1 2001 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology