The role of inflammation in the pathogenesis of heart failure

Kevin A. Lisman, Sonny J. Stetson, Michael M. Koerner, John A. Farmer, Guillermo Torre

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Heart failure is not a simple defect in the pumping function of cardiac muscle, but rather a complex systemic inflammatory disease affecting many organ systems. Recognition of this fact has led to new therapeutic interventions such as angiotensin-converting enzyme inhibitors and b-blockers, which have a significant impact on the quality of life and survival of patients with heart failure. During the course of heart failure, the steps involved in the activation of inflammation are now better understood. As a result, new therapies will develop that block, modify, or prevent these inflammatory changes, and supplement our armamentarium for providing better and longer lives for patients.

Original languageEnglish (US)
Pages (from-to)200-205
Number of pages6
JournalCurrent Cardiology Reports
Issue number3
StatePublished - Dec 1 2002

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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