The role of immunogenicity in cardiovascular disease

Michael Jan, Anthony T. Virtue, Meghanaben Pansuria, Jingshan Liu, Xinyu Xiong, Pu Fang, Shu Meng, Hong Wang, Xiao Feng Yang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recently, many of the complexities associated with cardiovascular diseases (CVD) have been unlocked. However, despite these breakthroughs, CVD and its related complications are the leading contributors of morbidity and mortality worldwide, which indicates the shortcomings of current treatment regimens and the need for continued research. Published data within the field clearly indicates that CVD are built on inflammation and autoimmune platforms, though a strong, fundamental understanding of the mechanisms remains elusive. Areas such as the mechanisms underlying increased immunogenicity of self-proteins in the cardiovascular system, the roles of immunogenic auto-antigens in eliciting inflammatory autoimmune responses, and the immunosuppressive mechanisms involved in controlling inflammatory and autoimmune cardiovascular diseases remain to be well-understood. We will delve into these topics and the advancements made within the field in this review. Specifically, we will concentrate on the innate and adaptive immune responses mediating immunogenicity; the mechanisms of inflammation and autoimmunity in atherogenesis; the mechanisms of inflammation and autoimmunity in diabetic atherosclerosis; immunogenicity and stem cell therapy; as well as immunogenicity and immunosuppression. In depth examination and comprehension of these topics will provide insight into the recent progress of the field and bring to the forefront potentially novel therapeutic avenues.

Original languageEnglish (US)
Title of host publicationCardiovascular Health and Chronomics
PublisherNova Science Publishers, Inc.
Pages123-163
Number of pages41
ISBN (Electronic)9781631170270
ISBN (Print)9781629489766
StatePublished - Jan 1 2014

Keywords

  • Atherosclerosis
  • Autoimmunity
  • Diabetes
  • Immunogenicity
  • Immunosuppression
  • Inflammation
  • Stem cell therapy

ASJC Scopus subject areas

  • Medicine(all)

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