The Role of Hemoglobin Denaturation and Band 3 Clustering in Red Blood Cell Aging

Philip S. Low, Stephen M. Waugh, Karen Zinke, Detlev Drenckhahn

Research output: Contribution to journalArticlepeer-review

293 Scopus citations

Abstract

As hemoglobin begins to denature, it forms hemichromes that cross-link the major erythrocyte membrane-spanning protein, band 3, into clusters. These clusters provide the recognition site for antibodies directed against senescent cells. These antibodies bind to the aged red cell and trigger its removal from circulation.

Original languageEnglish (US)
Pages (from-to)531-533
Number of pages3
JournalScience
Volume227
Issue number4686
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • General

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