Abstract

The difference between the female and male immune response to COVID-19 infection, and infections in general, is multifactorial. The well-known determiners of the immune response, such as X and Y chromosomes, sex hormones, and microbiota, are functionally interconnected and influence each other in shaping the organism's immunity. We focus our commentary on the interplay between the genetic sex and mitochondria and how this may affect a sex-dependent immune response in COVID-19 infection. Realizing the existence of these interactions may help in designing novel methods or fine-tuning the existing and routine therapies to fight COVID-19 and other infections.

Original languageEnglish (US)
Pages (from-to)629-634
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume181
Issue number8
DOIs
StatePublished - Aug 1 2020

Keywords

  • Betacoronavirus
  • Coronavirus Infections/drug therapy
  • Female
  • Humans
  • Male
  • Melatonin/therapeutic use
  • Mitochondria/physiology
  • Pandemics
  • Pneumonia, Viral/drug therapy
  • Sex Characteristics
  • Sex Chromosomes/physiology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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