The Role of Estrogen in Cardiac Metabolism and Diastolic Function

Shumin Li, Anisha A. Gupte

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Heart failure with preserved ejection fraction (HFpEF) has similar prevalence and prognosis as HF with reduced EF, but there is no approved treatment for HFpEF. HFpEF is common in postmenopausal women, which suggests that the absence of estrogen (E2) plays a role in its pathophysiology. With the country's growing elderly population, the prevalence of HFpEF is rapidly increasing. This has triggered a renewed urgency in finding novel approaches to preventing and slowing the progression of HFpEF. In this review, we address the role of E2 in left ventricular diastolic function and how it impacts women with HFpEF as well as animal models. We also discuss the primary potential mechanisms that represent critical nodes in the mechanistic pathways of HFpEF and how new treatments could be developed to target those mechanisms.

Original languageEnglish (US)
Pages (from-to)4-8
Number of pages5
JournalMethodist DeBakey cardiovascular journal
Issue number1
StatePublished - Jan 1 2017


  • Ca2+ homeostasis
  • cardiac hypertrophy
  • cardiac remodeling
  • estrogen
  • heart failure
  • left ventricular diastolic dysfunction
  • mitochondrial function
  • titin isoforms

ASJC Scopus subject areas

  • Medicine(all)


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