The role of DNA polymerase I-associated 5′-exonuclease in replication of coliphage M13 replicative-form DNA

Santanu Dasgupta; Sankar Mitra

doi:10.1016/0006-291X(77)90535-6

The role of DNA polymerase I-associated 5′-exonuclease in replication of coliphage M13 replicative-form DNA

Santanu Dasgupta, Sankar Mitra

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Abstract

The conversion of both parental- and progeny-nascent open circular M13 RF DNA into covalently closed RF I is drastically reduced in an E. coli mutant deficient in the 5′ → 3′ exonuclease associated with DNA polymerase I. The nascent progeny RF DNA also contains a significant proportion of fragments of smaller than unit length.

Original language	English (US)
Pages (from-to)	1108-1113
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	78
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(77)90535-6
State	Published - Oct 10 1977

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(77)90535-6

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title = "The role of DNA polymerase I-associated 5′-exonuclease in replication of coliphage M13 replicative-form DNA",

abstract = "The conversion of both parental- and progeny-nascent open circular M13 RF DNA into covalently closed RF I is drastically reduced in an E. coli mutant deficient in the 5′ → 3′ exonuclease associated with DNA polymerase I. The nascent progeny RF DNA also contains a significant proportion of fragments of smaller than unit length.",

author = "Santanu Dasgupta and Sankar Mitra",

year = "1977",

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AU - Mitra, Sankar

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Y1 - 1977/10/10

N2 - The conversion of both parental- and progeny-nascent open circular M13 RF DNA into covalently closed RF I is drastically reduced in an E. coli mutant deficient in the 5′ → 3′ exonuclease associated with DNA polymerase I. The nascent progeny RF DNA also contains a significant proportion of fragments of smaller than unit length.

AB - The conversion of both parental- and progeny-nascent open circular M13 RF DNA into covalently closed RF I is drastically reduced in an E. coli mutant deficient in the 5′ → 3′ exonuclease associated with DNA polymerase I. The nascent progeny RF DNA also contains a significant proportion of fragments of smaller than unit length.

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The role of DNA polymerase I-associated 5′-exonuclease in replication of coliphage M13 replicative-form DNA

Abstract

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