The role of depression pharmacogenetic decision support tools in shared decision making

Katarina Arandjelovic, Harris A. Eyre, Eric Lenze, Ajeet B. Singh, Michael Berk, Chad Bousman

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Patients discontinue antidepressant medications due to lack of knowledge, unrealistic expectations, and/or unacceptable side effects. Shared decision making (SDM) invites patients to play an active role in their treatment and may indirectly improve outcomes through enhanced engagement in care, adherence to treatment, and positive expectancy of medication outcomes. We believe decisional aids, such as pharmacogenetic decision support tools (PDSTs), facilitate SDM in the clinical setting. PDSTs may likewise predict drug tolerance and efficacy, and therefore adherence and effectiveness on an individual-patient level. There are several important ethical considerations to be navigated when integrating PDSTs into clinical practice. The field requires greater empirical research to demonstrate clinical utility, and the mechanisms thereof, as well as exploration of the ethical use of these technologies.

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalJournal of Neural Transmission
Issue number1
StatePublished - Jan 21 2019


  • Adherence
  • Antidepressants
  • Decision support tool
  • Pharmacogenetics
  • Psychoeducation
  • Shared decision making
  • Therapeutic alliance

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry


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