The role of cytokines in disease progression in heart failure

Kesavan Shan, Karla M. Kurrelmeyer, Yukihiro Seta, Feng Wang, Ziad Dibbs, Anita Deswal, Dorellyn Lee-Jackson, Douglas L. Mann

Research output: Contribution to journalReview articlepeer-review

96 Scopus citations


Recent studies have identified the importance of biologically active molecules such as neurohormones as mediators of disease progression in heart failure. More recently it has become apparent that in addition to neurohormones, another portfolio of biologically active molecules, termed cytokines, are also expressed in the setting of heart failure. This article reviews recent clinical and experimental material that suggests that the cytokines, much like the neurohormones, may represent another class of biologically active molecules that are responsible for the development and progression of heart failure.

Original languageEnglish (US)
Pages (from-to)218-223
Number of pages6
JournalCurrent Opinion in Cardiology
Issue number3
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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