The role of caveolin-1 in androgen insensitive prostate cancer

Vladimir Mouraviev; Likun Li; Salahaldin A. Tahir; Guang Yang; Terry L. Timme; Alexei Goltsov; Chengzhen Ren; Takefumi Satoh; Thomas M. Wheeler; Michael M. Ittmann; Brian J. Miles; Robert J. Amato; Dov Kadmon; Timothy C. Thompson

doi:10.1016/s0022-5347(05)64526-0

The role of caveolin-1 in androgen insensitive prostate cancer

Vladimir Mouraviev, Likun Li, Salahaldin A. Tahir, Guang Yang, Terry L. Timme, Alexei Goltsov, Chengzhen Ren, Takefumi Satoh, Thomas M. Wheeler, Michael M. Ittmann, Brian J. Miles, Robert J. Amato, Dov Kadmon, Timothy C. Thompson

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Purpose: We summarize the literature regarding androgen insensitive prostate cancer and caveolin-1. Caveolin-1 is a major structural component of caveolae, membrane micro-domains known to have important roles in signal transduction and lipid transport. Materials and Methods: A review of the literature relevant to androgen insensitive caveolin-1 and prostate cancer included the first published report in 1998 through those published in March 2002. Results: Caveolin-1 expression is increased in primary and metastatic human prostate cancer with highest levels observed after androgen ablation therapy. Recent studies have documented that caveolin-1 is secreted by prostate cancer cells and can be detected in the serum of men with prostate cancer. Conclusions: The results presented in this review establish that caveolin-1 is an autocrine/paracrine factor associated with androgen insensitive prostate cancer. They show the potential for caveolin-1 as a biomarker therapeutic target for this important malignancy.

Original language	English (US)
Pages (from-to)	1589-1596
Number of pages	8
Journal	Journal of Urology
Volume	168
Issue number	4 I
DOIs	https://doi.org/10.1016/s0022-5347(05)64526-0
State	Published - Oct 2002

Keywords

Androgens
Caveolins
Neoplasm metastasis
Prostate
Prostatic neoplasms

ASJC Scopus subject areas

Urology

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10.1016/s0022-5347(05)64526-0

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title = "The role of caveolin-1 in androgen insensitive prostate cancer",

abstract = "Purpose: We summarize the literature regarding androgen insensitive prostate cancer and caveolin-1. Caveolin-1 is a major structural component of caveolae, membrane micro-domains known to have important roles in signal transduction and lipid transport. Materials and Methods: A review of the literature relevant to androgen insensitive caveolin-1 and prostate cancer included the first published report in 1998 through those published in March 2002. Results: Caveolin-1 expression is increased in primary and metastatic human prostate cancer with highest levels observed after androgen ablation therapy. Recent studies have documented that caveolin-1 is secreted by prostate cancer cells and can be detected in the serum of men with prostate cancer. Conclusions: The results presented in this review establish that caveolin-1 is an autocrine/paracrine factor associated with androgen insensitive prostate cancer. They show the potential for caveolin-1 as a biomarker therapeutic target for this important malignancy.",

keywords = "Androgens, Caveolins, Neoplasm metastasis, Prostate, Prostatic neoplasms",

author = "Vladimir Mouraviev and Likun Li and Tahir, {Salahaldin A.} and Guang Yang and Timme, {Terry L.} and Alexei Goltsov and Chengzhen Ren and Takefumi Satoh and Wheeler, {Thomas M.} and Ittmann, {Michael M.} and Miles, {Brian J.} and Amato, {Robert J.} and Dov Kadmon and Thompson, {Timothy C.}",

year = "2002",

month = oct,

doi = "10.1016/s0022-5347(05)64526-0",

language = "English (US)",

volume = "168",

pages = "1589--1596",

journal = "Journal of Urology",

issn = "0022-5347",

publisher = "Wolters Kluwer Health",

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T1 - The role of caveolin-1 in androgen insensitive prostate cancer

AU - Mouraviev, Vladimir

AU - Li, Likun

AU - Tahir, Salahaldin A.

AU - Yang, Guang

AU - Timme, Terry L.

AU - Goltsov, Alexei

AU - Ren, Chengzhen

AU - Satoh, Takefumi

AU - Wheeler, Thomas M.

AU - Ittmann, Michael M.

AU - Miles, Brian J.

AU - Amato, Robert J.

AU - Kadmon, Dov

AU - Thompson, Timothy C.

PY - 2002/10

Y1 - 2002/10

N2 - Purpose: We summarize the literature regarding androgen insensitive prostate cancer and caveolin-1. Caveolin-1 is a major structural component of caveolae, membrane micro-domains known to have important roles in signal transduction and lipid transport. Materials and Methods: A review of the literature relevant to androgen insensitive caveolin-1 and prostate cancer included the first published report in 1998 through those published in March 2002. Results: Caveolin-1 expression is increased in primary and metastatic human prostate cancer with highest levels observed after androgen ablation therapy. Recent studies have documented that caveolin-1 is secreted by prostate cancer cells and can be detected in the serum of men with prostate cancer. Conclusions: The results presented in this review establish that caveolin-1 is an autocrine/paracrine factor associated with androgen insensitive prostate cancer. They show the potential for caveolin-1 as a biomarker therapeutic target for this important malignancy.

AB - Purpose: We summarize the literature regarding androgen insensitive prostate cancer and caveolin-1. Caveolin-1 is a major structural component of caveolae, membrane micro-domains known to have important roles in signal transduction and lipid transport. Materials and Methods: A review of the literature relevant to androgen insensitive caveolin-1 and prostate cancer included the first published report in 1998 through those published in March 2002. Results: Caveolin-1 expression is increased in primary and metastatic human prostate cancer with highest levels observed after androgen ablation therapy. Recent studies have documented that caveolin-1 is secreted by prostate cancer cells and can be detected in the serum of men with prostate cancer. Conclusions: The results presented in this review establish that caveolin-1 is an autocrine/paracrine factor associated with androgen insensitive prostate cancer. They show the potential for caveolin-1 as a biomarker therapeutic target for this important malignancy.

KW - Androgens

KW - Caveolins

KW - Neoplasm metastasis

KW - Prostate

KW - Prostatic neoplasms

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The role of caveolin-1 in androgen insensitive prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

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