The role of caveolin-1 in androgen insensitive prostate cancer

Vladimir Mouraviev, Likun Li, Salahaldin A. Tahir, Guang Yang, Terry L. Timme, Alexei Goltsov, Chengzhen Ren, Takefumi Satoh, Thomas M. Wheeler, Michael M. Ittmann, Brian J. Miles, Robert J. Amato, Dov Kadmon, Timothy C. Thompson

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Purpose: We summarize the literature regarding androgen insensitive prostate cancer and caveolin-1. Caveolin-1 is a major structural component of caveolae, membrane micro-domains known to have important roles in signal transduction and lipid transport. Materials and Methods: A review of the literature relevant to androgen insensitive caveolin-1 and prostate cancer included the first published report in 1998 through those published in March 2002. Results: Caveolin-1 expression is increased in primary and metastatic human prostate cancer with highest levels observed after androgen ablation therapy. Recent studies have documented that caveolin-1 is secreted by prostate cancer cells and can be detected in the serum of men with prostate cancer. Conclusions: The results presented in this review establish that caveolin-1 is an autocrine/paracrine factor associated with androgen insensitive prostate cancer. They show the potential for caveolin-1 as a biomarker therapeutic target for this important malignancy.

Original languageEnglish (US)
Pages (from-to)1589-1596
Number of pages8
JournalJournal of Urology
Volume168
Issue number4 I
DOIs
StatePublished - Oct 2002

Keywords

  • Androgens
  • Caveolins
  • Neoplasm metastasis
  • Prostate
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'The role of caveolin-1 in androgen insensitive prostate cancer'. Together they form a unique fingerprint.

Cite this