The Role of Calcium Signaling in Melanoma

Haoran Zhang, Zhe Chen, Aijun Zhang, Anisha A. Gupte, Dale J. Hamilton

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Calcium signaling plays important roles in physiological and pathological conditions, including cutaneous melanoma, the most lethal type of skin cancer. Intracellular calcium concentration ([Ca2+]i), cell membrane calcium channels, calcium related proteins (S100 family, E-cadherin, and calpain), and Wnt/Ca2+ pathways are related to melanogenesis and melanoma tumorigenesis and progression. Calcium signaling influences the melanoma microenvironment, including immune cells, extracellular matrix (ECM), the vascular network, and chemical and physical surroundings. Other ionic channels, such as sodium and potassium channels, are engaged in calcium-mediated pathways in melanoma. Calcium signaling serves as a promising pharmacological target in melanoma treatment, and its dysregulation might serve as a marker for melanoma prediction. We documented calcium-dependent endoplasmic reticulum (ER) stress and mitochondria dysfunction, by targeting calcium channels and influencing [Ca2+]i and calcium homeostasis, and attenuated drug resistance in melanoma management.

Original languageEnglish (US)
Article number1010
JournalInternational journal of molecular sciences
Issue number3
StatePublished - Jan 18 2022


  • Calcium
  • Melanoma
  • Melanoma microenvironment
  • Mitochondria
  • Progression
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Tumor Microenvironment
  • Drug Resistance, Neoplasm
  • Melanoma/metabolism
  • Endoplasmic Reticulum Stress
  • Calcium Signaling
  • Wnt Signaling Pathway

ASJC Scopus subject areas

  • Molecular Biology
  • Spectroscopy
  • Catalysis
  • Inorganic Chemistry
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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