The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression

Research output: Contribution to journalArticle

Dingcheng Gao, Vivek Mittal

Emerging evidence from murine models suggests that tumor-specific endocrine factors systemically stimulate the quiescent bone marrow (BM) compartment, resulting in the expansion, mobilization and recruitment of BM progenitor cells. Discrete subsets of tumor-instigated BM-derived progenitor cells support tumor progression and metastasis by regulating angiogenesis, inflammation and immune suppression. Notably, clinical studies have begun to reveal that increased BM recruitment in tumors is associated with poor prognosis. Thus, the BM-derived tumor microenvironment is an attractive therapeutic target, and drugs targeting the components of the microenvironment are currently in clinical trials. Here, we focus on recent advances and emerging concepts regarding the intriguing role of BM-derived cells in tumor growth, metastasis initiation and progression, and we discuss future directions in the context of novel diagnostic and therapeutic opportunities.

Original languageEnglish
Pages (from-to)333-343
Number of pages11
JournalTrends in Molecular Medicine
Volume15
Issue number8
DOIs
StatePublished - Aug 1 2009

PMID: 19665928

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The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression. / Gao, Dingcheng; Mittal, Vivek.

In: Trends in Molecular Medicine, Vol. 15, No. 8, 01.08.2009, p. 333-343.

Research output: Contribution to journalArticle

Harvard

Gao, D & Mittal, V 2009, 'The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression' Trends in Molecular Medicine, vol. 15, no. 8, pp. 333-343. https://doi.org/10.1016/j.molmed.2009.06.006

APA

Gao, D., & Mittal, V. (2009). The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression. Trends in Molecular Medicine, 15(8), 333-343. https://doi.org/10.1016/j.molmed.2009.06.006

Vancouver

Gao D, Mittal V. The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression. Trends in Molecular Medicine. 2009 Aug 1;15(8):333-343. https://doi.org/10.1016/j.molmed.2009.06.006

Author

Gao, Dingcheng ; Mittal, Vivek. / The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression. In: Trends in Molecular Medicine. 2009 ; Vol. 15, No. 8. pp. 333-343.

BibTeX

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title = "The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression",
abstract = "Emerging evidence from murine models suggests that tumor-specific endocrine factors systemically stimulate the quiescent bone marrow (BM) compartment, resulting in the expansion, mobilization and recruitment of BM progenitor cells. Discrete subsets of tumor-instigated BM-derived progenitor cells support tumor progression and metastasis by regulating angiogenesis, inflammation and immune suppression. Notably, clinical studies have begun to reveal that increased BM recruitment in tumors is associated with poor prognosis. Thus, the BM-derived tumor microenvironment is an attractive therapeutic target, and drugs targeting the components of the microenvironment are currently in clinical trials. Here, we focus on recent advances and emerging concepts regarding the intriguing role of BM-derived cells in tumor growth, metastasis initiation and progression, and we discuss future directions in the context of novel diagnostic and therapeutic opportunities.",
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